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Publikováno v:
Molecular Endocrinology. 12:954-961
As pituitary leukemia-inhibitory factor (LIF) mediates neuroimmune signals to the hypothalamo-pituitary-adrenal axis, we tested the role of intracellular SOCS-3 in corticotroph function. SOCS-3, a cytokine-inducible protein of the suppressor of cytok
Publikováno v:
Molecular Endocrinology. 9:1791-1803
PML (promyelocytic leukemia) is a protein involved in the t (15;17) translocation of promyelocytic leukemia and is mainly localized in nuclear bodies. Here we show that PML exerts a very powerful enhancing activity (up to 20-fold) on the transactivat
Publikováno v:
Molecular Endocrinology. 7:1589-1595
The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid trans
Publikováno v:
Molecular Endocrinology. 6:1310-1317
The mechanism responsible for the stimulation of thyroglobulin (Tg) gene expression by insulin and insulin-like growth factor I (IGF-I) in rat thyroid FRTL-5 cells has been investigated. Both insulin and IGF-I stimulate transcription from the Tg prom
Publikováno v:
Molecular Endocrinology. 5:854-859
nur77 is a growth factor-inducible immediate early gene that encodes a protein with extensive sequence homology to members of the steroid/thyroid hormone receptor superfamily. By analogy to steroid receptors, the Nur77 protein is thought to act as a
Autor:
Donald B. Jump, Gerald J. Lepar
Publikováno v:
Molecular Endocrinology. 3:1207-1214
3T3-F442A cells differentiate from preadipocytes to adipocytes when cultured in medium containing fetal calf serum and insulin. We examined the regulation of the S14 gene in 3T3-F442A preadipocytes and adipocytes to determine whether these cells woul