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Autor:
Karen L. Chen, Sarah Li, Yiru Chen Zhao, Alexander E. Lipka, Partha S. Ray, Eylem Kulkoyluoglu, Rebecca L. Smith, Tania Ray, Jamie N. Holloway, Kadriye Hieronymi, Yosef Landesman, Zeynep Madak-Erdogan, Kinga Wrobel
Publikováno v:
Molecular Endocrinology
Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be re
Autor:
Ryo Maekawa, Takuya Kajimura, Shun Sato, Hiromi Asada, Yoshiaki Yamagata, Shigeru Yamamoto, Hiroshi Tamura, Kosuke Jozaki, Norihiro Sugino, Isao Tamura, Maki Okada, Lifa Lee
Publikováno v:
Molecular Endocrinology. 30:335-347
The mechanism controlling tissue-specific expression of estrogen receptor 1 (ESR1) is unclear. In other genes, DNA methylation of a region called the tissue-dependent and differentially methylated region (T-DMR) has been associated with tissue-specif
Autor:
Yasushi Saeki, Hiroyuki Nishikawa, Fumiaki Ohtake, Keiji Takana, Maiko Okada, Wenwen Wu, Tomohiko Ohta
Publikováno v:
Molecular Endocrinology. 29:1646-1657
Estrogen receptor (ER)α is a well-characterized ligand-dependent transcription factor. However, the global picture of its nongenomic functions remains to be illustrated. Here, we demonstrate a novel function of ERα during mitosis that facilitates e
Autor:
Daniel Yagoub, Gyorgy Hutvagner, Wengen Wu, Diana Hatoum, Angelina J. Lay, Jack H. Lai, Sarah Bajan, Rosetta Martiniello-Wilks, Dominik Kaczorowski, Marc R. Wilkins, Pu Xia, Eileen M. McGowan
Publikováno v:
Molecular Endocrinology. 28:1899-1915
Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to therapy. SK1 inhibitors are currently being invest
Publikováno v:
Molecular Endocrinology. 28:1522-1533
Proper gene regulation is essential for proper organismal development and appropriate responses to external stimuli. Specialized factors, termed master regulators, are often responsible for orchestrating the molecular events that result from signalin
Autor:
Sean M. Grimmond, Christine L. Clarke, Aaron G. Smith, Peter J. Leedman, John W. Funder, Joel M. Goode, Peter Bailey, Wayne D. Tilley, Peter J. Fuller, George E.O. Muscat, Dennis H. Dowhan, Natalie A. Eriksson, Tae Gyu Oh, Evan R. Simpson, Eloise Dray
Publikováno v:
Molecular Endocrinology. 28:1166-1185
Protein arginine methyltransferases (PRMTs) methylate arginine residues on histones and target transcription factors that play critical roles in many cellular processes, including gene transcription, mRNA splicing, proliferation, and differentiation.
Publikováno v:
Molecular Endocrinology. 28:846-859
Transcription of the HER2 oncogene can be repressed by estrogen (E2). We now show that, a splice isoform of the nuclear receptor coactivator AIB1, AIB1-Δ4, is able to reverse E2 repression of HER2 gene expression in breast cancer cells. The first 22
Autor:
Matthew J. Schiewer, Karen E. Knudsen, Andrea R. Daniel, Christy R. Hagan, Gwen E. Dressing, Caroline H. Diep, Carol A. Lange, Todd P. Knutson
Publikováno v:
Molecular Endocrinology. 28:442-457
The progesterone receptor (PR) and its coactivators are direct targets of activated cyclin-dependent kinases (CDKs) in response to peptide growth factors, progesterone, and deregulation of cell cycle inhibitors. Herein, using the T47D breast cancer m
Publikováno v:
Molecular Endocrinology. 28:331-343
Plasma membrane-bound carboxypeptidase-D (CPD) cleaves C-terminal arginine from extracellular substrates. In the cell, arginine is converted to nitric oxide (NO). We have reported that up-regulation of CPD mRNA/protein levels by 17β-estradiol and pr
Publikováno v:
Molecular Endocrinology. 28:197-207
Insulin, an established mitogen that promotes breast cancer cell growth, has been implicated in the link between obesity and an increased risk of breast cancer. However, the current understanding of signaling pathways that mediate the mitogenic actio