Zobrazeno 1 - 10
of 11
pro vyhledávání: ''
Autor:
Sujit S. Nair, Darrell W Brann, Dujin Zhou, Rajib Rajhans, Valerie Cortez, Hareesh B. Nair, Ratna K. Vadlamudi, Nameer B. Kirma, Alan E.C. Holden, Kijima Ikuko, Rajeshwar Rao Tekmal, Shiuan Chen
Publikováno v:
Molecular Endocrinology. 22:649-664
In situ estrogen synthesis is implicated in tumor cell proliferation through autocrine or paracrine mechanisms especially in postmenopausal women. Several recent studies demonstrated activity of aromatase, an enzyme that plays a critical role in estr
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav
Autor:
Olivier Goupille, Andrew Ziemiecki, Wolfgang Doppler, Claudia Soratroi, Martin Tonko, Sibylle Tonko-Geymayer, Charles H. Streuli, Reinhard Kofler, Akihiko Yoshimura
Publikováno v:
Molecular Endocrinology. 16:1680-1695
The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal tr
Autor:
Joyce Cheung, David F. Smith
Publikováno v:
Molecular Endocrinology. 14:939-946
In the 3 yr since William Pratt and David Toft published their comprehensive review of chaperone interactions with steroid receptors (1), progress has been made on several fronts that gives a better appreciation for the range of functions that chaper
Publikováno v:
Molecular Endocrinology. 12:954-961
As pituitary leukemia-inhibitory factor (LIF) mediates neuroimmune signals to the hypothalamo-pituitary-adrenal axis, we tested the role of intracellular SOCS-3 in corticotroph function. SOCS-3, a cytokine-inducible protein of the suppressor of cytok
Autor:
Marie Pierre Gaub, Huib A.P. Pols, Janet L. Stein, J.P.T.M. van Leeuwen, Gary S. Stein, H. F. Deluca, J. Prahl, Jan C. Birkenhäger, A. Staal, A. J. Van Wijnen, J. B. Lian
Publikováno v:
Scopus-Elsevier
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs). Sequence
Publikováno v:
Molecular Endocrinology. 10:826-836
Interferon-gamma (IFN gamma) is known to suppress the expression of thyroid-specific genes, such as thyroglobulin, thyroid peroxidase, and the TSH receptor (TSHR). In the present study, we show that this reflects, in part, a transcriptional action me
Publikováno v:
Molecular Endocrinology. 9:1791-1803
PML (promyelocytic leukemia) is a protein involved in the t (15;17) translocation of promyelocytic leukemia and is mainly localized in nuclear bodies. Here we show that PML exerts a very powerful enhancing activity (up to 20-fold) on the transactivat
Publikováno v:
Molecular Endocrinology. 8:1798-1806
The development of endocrine cell types within the pancreas is thought to involve the progressive restriction of pluripotential stem cells, which gives rise to the four major cell types: insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-
Publikováno v:
Molecular Endocrinology. 7:1589-1595
The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid trans