Zobrazeno 1 - 10
of 43
pro vyhledávání: ''
Autor:
Darawan Pinthong, Supachoke Mangmool, Sarawuth Phosri, Motohiro Nishida, Tsukasa Shimauchi, Tananat Denkaew, Warisara Parichatikanond
Publikováno v:
Molecular Endocrinology. 30:118-132
Insulin resistance is a condition in which cells are defective in response to the actions of insulin in tissue glucose uptake. Overstimulation of β-adrenergic receptors (βARs) leads to the development of heart failure and is associated with the pat
Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Autor:
Ulrike Henrion, Martin Fraunholz, Behnam Hessabi, Robert Smail Jack, Annett Ostmann, Anke Karkour, Meike Dahlhaus, Piotr Grabarczyk, Reinhard Walther, Gabriele Wolf, Bernd Giese
Publikováno v:
Molecular Endocrinology. 24:2331-2342
The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element. To analyze the role of
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy
Autor:
E. Dale Abel, Adam R. Wende, Sandra Sena, Benjamin Wayment, Derek LeRoith, Heather A. Theobald, Crystal Sloan, Sheldon E. Litwin, Martin Holzenberger, Jaetaek Kim, Jamie Soto
Publikováno v:
Molecular Endocrinology. 22:2531-2543
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1R
Autor:
Erik C. Rocheford, Tara L. Mullarkey, Nico Mitro, Xue Li, Enrique Saez, Patrick Kennedy, S. Renee Commerford, Leo Vargas, Puiying A. Mak, Suzanne E. Dorfman
Publikováno v:
Molecular Endocrinology. 21:3002-3012
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with synthetic LXR ligands enhances glucose tolerance, inducing changes in gene expression expected
Publikováno v:
Molecular Endocrinology. 21:2785-2794
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed to investigate the function of miRNAs in type 2 diabetes mellit
Autor:
Frank A. Simmen, Thomas M. Badger, Ling He, John C. Marecki, Ginette Serrero, Martin J. J. Ronis
Publikováno v:
Molecular Endocrinology. 21:2541-2550
Routine consumption of alcohol at low doses is associated with decreased risk of acquiring type 2 diabetes, whereas chronic and excessive alcohol consumption increases the risk. Although there is good epidemiologic evidence for these biphasic effects
Autor:
Alessandra K Cardozo, Joachim Størling, Daisy Crispim, Fernanda Ortis, Decio L. Eizirik, Thomas Mandrup-Poulsen
Publikováno v:
Molecular Endocrinology. 20:1867-1879
Cytokines, such as IL-1beta and TNF-alpha, contribute to pancreatic beta-cell death in type 1 diabetes mellitus. The transcription factor nuclear factor-kappaB (NF-kappaB) mediates cytokine-induced beta-cell apoptosis. Paradoxically, NF-kappaB has mo
Autor:
Barton Luke Wicksteed, Christopher D. Green, L. Karl Olson, Katrina D. Linning, Diana Z. Ye, Vincent Poitout, Maria F. Pino
Publikováno v:
Molecular Endocrinology. 19:1343-1360
Chronic exposure of pancreatic beta-cells to elevated glucose reduces insulin gene promoter activity, and this is associated with diminished binding of two beta-cell-enriched transcription factors, Pdx-1 and MafA. In this study using INS-1 beta-cells