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Publikováno v:
Molecular Endocrinology. 29:528-541
Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the underlying mechanisms of PGRN in the regulation of insulin sensitivity and autophagy remain elusive. In this study, we aime
Publikováno v:
Molecular Endocrinology. 25:492-502
Acute insulin resistance is common after injury, infection, and critical illness. To investigate the role of reactive oxygen species (ROS) in critical illness diabetes, we measured hepatic ROS, which rapidly increased in mouse liver. Overexpression o
Autor:
Erik C. Rocheford, Tara L. Mullarkey, Nico Mitro, Xue Li, Enrique Saez, Patrick Kennedy, S. Renee Commerford, Leo Vargas, Puiying A. Mak, Suzanne E. Dorfman
Publikováno v:
Molecular Endocrinology. 21:3002-3012
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Treatment of insulin-resistant mice with synthetic LXR ligands enhances glucose tolerance, inducing changes in gene expression expected
Autor:
Frank A. Simmen, Thomas M. Badger, Ling He, John C. Marecki, Ginette Serrero, Martin J. J. Ronis
Publikováno v:
Molecular Endocrinology. 21:2541-2550
Routine consumption of alcohol at low doses is associated with decreased risk of acquiring type 2 diabetes, whereas chronic and excessive alcohol consumption increases the risk. Although there is good epidemiologic evidence for these biphasic effects
Autor:
Timothy J. Kieffer, Ni T. Lam, Junfeng Wang, Jeshurun Tse, Cynthia T. Luk, Jay K. Kolls, Anthony T. Cheung, Michael Bryer-Ash, Jamie T. Lewis
Publikováno v:
Molecular Endocrinology. 18:1333-1345
Leptin has been shown to improve insulin sensitivity and glucose metabolism in obese diabetic ob/ob mice, yet the mechanisms remain poorly defined. We found that 2 d of leptin treatment improved fasting but not postprandial glucose homeostasis, sugge
Publikováno v:
Molecular Endocrinology. 14:1472-1482
Insulin-like growth factor binding protein 2 (IGFBP-2) is one member of the family of IGF binding proteins believed to have both endocrine functions elicited by modulating serum IGF half-life and transport as well as autocrine/paracrine functions tha
Publikováno v:
Molecular Endocrinology. 11:997-1007
The growth-promoting activity of GH, the principal hormonal determinant of body size, is mediated by insulin-like growth factor I (IGF-I). Most of the IGF-I in plasma circulates in a 150-kDa complex that contains IGF-binding protein-3 (IGFBP-3) and a
Publikováno v:
Molecular Endocrinology. 10:622-630
Insulin-dependent diabetes mellitus is associated with decreased levels of circulating insulin-like growth factor binding protein-3 (IGFBP-3), which are restored toward normal by treatment with insulin and/or infusion of insulin-like growth factor-I
Autor:
Lynn R. Carnaghi, Stephen J. Giddings
Publikováno v:
Molecular Endocrinology. 6:1665-1672
Insulin gene expression has been demonstrated in nonpancreatic tissues early in development, suggesting that this hormone might have actions significant for the differentiating embryo. Because such actions imply ligand-receptor binding, we quantified
Autor:
J. Schwander, Christoph Schmid, Ernst Rudolf Prof Dr Froesch, J Zapf, Peter J. Meier, J.-L. Mary, M. Boni-Schnetzler, B. Zimmerli
Publikováno v:
Molecular Endocrinology. 4:1320-1326
The goal of this study was to find out whether GH or insulin regulate the mRNA expression of the fetal binding protein of insulin-like growth factor (IGFBP-2). Primary hepatocytes from adult rats were used as a test system. IGFBP-2 mRNA was abundant