Zobrazeno 1 - 10
of 44
pro vyhledávání: ''
Publikováno v:
Molecular Endocrinology. 29:396-410
Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previousl
Autor:
Catharine L. Smith, Vineela Kadiyala
Publikováno v:
Molecular Endocrinology. 28:607-621
Lysine deacetylases have been known to regulate nuclear receptor function for many years. In the unliganded state, nuclear receptors that form heterodimers with retinoid X receptors, such as the retinoic acid and thyroid hormone receptors, associate
Autor:
Patrick M. Sexton, Denise Wootten, Emilia Elizabeth Savage, Laurence J. Miller, Arthur Christopoulos, Cassandra Koole
Publikováno v:
Molecular Endocrinology. 27:1234-1244
The glucagon-like peptide-1 receptor (GLP-1R) controls the physiological responses to the incretin hormone glucagon-like peptide-1 and is a major therapeutic target for the treatment of type 2 diabetes, owing to the broad range of effects that are me
Publikováno v:
Molecular Endocrinology. 25:611-620
TNF, a proinflammatory and immune-regulatory cytokine, is a potent apoptotic stimulus in vitro. However, there have been few examples of a physiologic role for TNF-induced apoptosis in vivo. Here, we describe a novel role for TNF in prostate epitheli
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Autor:
Matthew R. Redinbo, Steven A. Kliewer, Linda B. Moore, Sompop Bencharit, Li Peng, Jillian Orans, Yu Xue
Publikováno v:
Molecular Endocrinology. 21:1028-1038
The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol. In response to these ligands, the receptor co
Publikováno v:
Molecular Endocrinology. 19:1501-1515
The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distributio
Autor:
Anthony W. Norman, June E. Bishop, Christopher J. Olivera, Laura P. Zanello, Johanna A. Huhtakangas
Publikováno v:
Molecular Endocrinology. 18:2660-2671
The steroid hormone 1α,25(OH)2-vitamin D3 (1,25D) regulates gene transcription through a nuclear receptor [vitamin D receptor (VDR)] and initiation of rapid cellular responses through a putative plasma membrane-associated receptor (VDRmem). This stu
Autor:
Carol A. Lange
Publikováno v:
Molecular Endocrinology. 18:269-278
In classical models of nuclear steroid hormone receptor function, ligand binds receptor, heat shock proteins dissociate, and receptor dimers enter or are withheld in the nucleus and interact with coregulatory molecules to mediate changes in gene expr