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Publikováno v:
Molecular Endocrinology. 5:1003-1012
A protein kinase capable of phosphorylating basic fibroblast growth factor (FGF) can be localized on the outer cell surface of human hepatoma cells (SK-Hep cells). The addition of [gamma-32P]ATP, but not H3(32)PO4, results in a rapid (less than 10 mi
Publikováno v:
Molecular Endocrinology. 4:1377-1385
We investigated the regulation of mRNAs coding for acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), and transforming growth factor-alpha (TGF alpha) in cultures of human neonatal foreskin fibroblasts, keratinocytes, and
Publikováno v:
Molecular Endocrinology. 3:225-231
Human tumors were analyzed for the presence of mRNA coding for basic fibroblast growth factor (basic FGF). Basic FGF transcript levels were consistently elevated in schwannoma samples (five acoustic neuromas and two spinal schwannomas) ranging from 9
Publikováno v:
Molecular Endocrinology. 2:1196-1201
The human astrocytoma cell line U87-MG expressed two major basic fibroblast growth factor (FGF) mRNA transcripts of 7.0 and 3.7 kilobase (kb), as well as several low abundance transcripts of lower mol wt (1.0-1.8 kb). The phorbol ester phorbol-12,13-
Publikováno v:
Molecular Endocrinology. 3:552-558
In MCF7 human breast cancer cells, cathepsin-D and pS2 mRNAs are specifically and directly induced by estrogens at the transcriptional level. We studied the regulation of expression of these two genes by growth factors that are also mitogenic in this
Publikováno v:
Molecular Endocrinology. 3:744-748
Basic fibroblast growth factor (bFGF) is a potent endothelial cell mitogen whose actions are mediated by binding to specific cell surface receptors on a variety of cell types. However, the amino acid sequence of bFGF does not contain a classical sign