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Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Publikováno v:
Molecular Endocrinology. 22:273-286
Increased androgen receptor (AR) levels are associated with prostate cancer progression to androgen independence and therapy resistance. Evidence has suggested that chronic inflammation is closely linked to various cancers including prostate cancer.
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Publikováno v:
Molecular Endocrinology. 19:312-326
We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3′-k
Publikováno v:
Molecular Endocrinology. 11:997-1007
The growth-promoting activity of GH, the principal hormonal determinant of body size, is mediated by insulin-like growth factor I (IGF-I). Most of the IGF-I in plasma circulates in a 150-kDa complex that contains IGF-binding protein-3 (IGFBP-3) and a
Autor:
Marie Pierre Gaub, Huib A.P. Pols, Janet L. Stein, J.P.T.M. van Leeuwen, Gary S. Stein, H. F. Deluca, J. Prahl, Jan C. Birkenhäger, A. Staal, A. J. Van Wijnen, J. B. Lian
Publikováno v:
Scopus-Elsevier
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs). Sequence
Publikováno v:
Molecular Endocrinology. 10:713-722
Bone loss observed in postmenopausal women is clearly associated with a decrease in estrogen levels. Interleukin 6 (IL-6), a multifunctional cytokine involved in osteoclast differentiation, is secreted by osteoblasts and appears to be a key molecule
Publikováno v:
Molecular Endocrinology. 9:1791-1803
PML (promyelocytic leukemia) is a protein involved in the t (15;17) translocation of promyelocytic leukemia and is mainly localized in nuclear bodies. Here we show that PML exerts a very powerful enhancing activity (up to 20-fold) on the transactivat
Publikováno v:
Molecular Endocrinology. 9:902-912
Insulin-like growth factor II (IGF-II)-overexpressing NIH 3T3 cells were used to examine regulation of insulin-like growth factor binding protein (IGFBP) and mannose 6-phosphate (M6P)/IGF-II receptor expression. Ligand blot analysis of conditioned me
Publikováno v:
Molecular Endocrinology. 8:782-793
The role of testosterone (T) and 17 beta-estradiol (E2) in the control of chinook salmon gonadotropin II beta subunit (sGTHII beta) gene was examined. Both E2 and T specifically stimulated GTHII beta gene expression in cultured juvenile rainbow trout