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Autor:
Adolfo Garcia-Ocaña, Ann Marie Segal, Juan Carlos Alvarez-Perez, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 29 (2015): 542–547. doi:10.1210/me.2014-1273
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
info:cnr-pdr/source/autori:Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE./titolo:Anti-incretin, Anti-proliferative Action of Dopamine on ?-Cells./doi:10.1210%2Fme.2014-1273/rivista:Molecular endocrinology (Baltim. Md.)/anno:2015/pagina_da:542/pagina_a:547/intervallo_pagine:542–547/volume:29
Human islet ?-cells exploit an autocrine dopamine (DA)-mediated inhibitory circuit to regulate insulin secretion. ?-Cells also express the DA active transporter and the large neutral amino acid transporter heterodimer enabling them to import circulat
Publikováno v:
Molecular Endocrinology. 27:1198-1207
Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. Recent data, however, suggest a plausible physiologic ro
Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Publikováno v:
Molecular Endocrinology. 14:1472-1482
Insulin-like growth factor binding protein 2 (IGFBP-2) is one member of the family of IGF binding proteins believed to have both endocrine functions elicited by modulating serum IGF half-life and transport as well as autocrine/paracrine functions tha
Publikováno v:
Molecular Endocrinology. 14:1147-1161
Various mediators, including cytokines, growth factors, homeotic gene products, and prostaglandins (PGs), participate in the implantation process in an autocrine, paracrine, or juxtacrine manner. However, interactions among these factors that result
Publikováno v:
Molecular Endocrinology. 11:2038-2047
In this report we show that extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2) respond differently to signals that elicit proliferation and/or differentiation of myoblasts using the C2C12 cell line and nondifferentiating mutant NFB4 cells
Autor:
Brian P. Mullaney, Michael K. Skinner
Publikováno v:
Molecular Endocrinology. 6:2103-2113
The potential role of transforming growth factor-alpha (TGF-alpha) as a mediator of cell-cell interactions in the growth and development of the testis was examined. Developing rat testes were collected, and preparations of mesenchymal-derived peritub
Publikováno v:
Molecular Endocrinology. 6:1825-1833
Transforming growth factor-beta 1 (TGF-beta 1) is known to inhibit cell growth and proliferation of many estrogen-responsive normal and transformed cells. The effect of this polypeptide growth factor on the estrogen-responsive pituitary lactotropes h
Publikováno v:
Molecular Endocrinology. 6:1774-1780
To test the hypothesis that insulin-like growth factor-I (IGF-I) affects the growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, a cell line (MD-IGF-I) was originated from MAC-T cells by cotransfection with a cons
Publikováno v:
Molecular Endocrinology. 3:976-983
We have previously reported the immunohistochemical localization of transforming growth factor-alpha (TGF alpha) in the intact bovine anterior pituitary gland. Furthermore, we have purified TGF alpha from the conditioned medium of cell cultures deriv