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Publikováno v:
Molecular Endocrinology. 9:691-705
A synchrony between the activated state of the blastocyst and differentiation of the uterus to the receptive state is essential to the process of implantation. This process is directed by progesterone (P4) and estrogen. The mechanism by which P4 diff
Publikováno v:
Molecular Endocrinology. 8:545-557
Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate insulin receptor substrate 1 (IRS-1), which in turn associates with and activates the enzyme phosphatidylinositol 3-kinase (PI
Autor:
Malcolm J. Low, T R Kumar
Publikováno v:
Molecular Endocrinology. 7:898-906
Transgenic mice that express a 10-kilobase human FSH beta (hFSH beta) gene exclusively in pituitary gonadotropes were used to study the regulation of hFSH beta gene expression by gonadal steroids. For comparison, the mouse FSH beta (mFSH beta) gene w
Autor:
Anne E. Wallis, R H Devlin
Publikováno v:
Molecular Endocrinology. 7:409-422
Insulin-like growth factor (IGF-I) is a single chain, 70-amino acid, peptide hormone, which is essential to the process of growth and differentiation in higher vertebrates. IGF-I exhibits a very high degree of conservation throughout vertebrate evolu
Autor:
Maria Slomczynska, Arun K. Roy, Chung S. Song, Tekmal R. Rao, W. F. Demyan, Song Her, Dong S. Kim, Bandana Chatterjee, Wolfgang Gallwitz
Publikováno v:
Molecular Endocrinology. 6:589-597
Mammalian estrogen sulfotransferase (EST; EC 2.8.2.4) sulfurylates the hydroxyl group of estrogenic steroids by transferring the sulfate from a cosubstrate adenosine 3'-phosphate-5'-phosphosulfate. Sulfurylated steroids do not bind to the estrogen re
Autor:
Danielle Naville, Judith R. Head, J. Ian Mason, Diane S. Keeney, Graham Jenkin, Barbara A. Murry
Publikováno v:
Molecular Endocrinology. 5:1090-1100
In the steroidogenic pathways present in the gonads and adrenal cortex, 3 beta-hydroxysteroid dehydrogenase isomerase (3 beta HSD) is a key enzyme which controls the formation of delta 4-3-ketosteroids from delta 5-3 beta-hydroxysteroids. Herein, we
Publikováno v:
Molecular Endocrinology. 4:1438-1443
When a human fetal muscle cDNA library was screened with the human thyroid hormone receptor alpha 2 cDNA at low stringency, we found a weakly hybridizing cDNA. The sequence of the insert was 2498 basepairs, with an open reading frame of 1794 basepair
Autor:
Arthur Gutierrez-Hartmann, William M. Wood, Daniel C. Rule, David F. Gordon, Robert H. Eckel, Mary V. Raynolds, Paul D. Awald
Publikováno v:
Molecular Endocrinology. 4:1416-1422
Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Isoproterenol, a beta-adrenergic agonist, decreases LPL enzyme activity, whereas insulin increases LPL activity. We have isolated an 868-basepair rat LPL cDNA c
Autor:
Masahiro Nishi, Donald F. Steiner
Publikováno v:
Molecular Endocrinology. 4:1192-1198
The degu, Octodon degus, is a South American hystricomorph rodent that is of interest because it develops spontaneous diabetes mellitus and has been found to have islet amyloidosis. To help clarify these problems we have cloned cDNAs encoding islet a
Autor:
Barry J. Goldstein, Alana L. Dudley
Publikováno v:
Molecular Endocrinology. 4:235-244
To investigate whether alterations in the polypeptide structure of the insulin receptor might explain the heterogeneity observed in its properties between species and in different tissues, we obtained the complete primary structure of the rat liver i