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Autor:
Wentian Yang, Jincai Luo, Benjamin G. Neel, Si Qing Zhang, Burkhart Schraven, Gengyun Wen, Trever G. Bivona, Julie A. Thompson, Toshiyuki Araki, Mark R. Philips, Maria I. Kontaridis
Publikováno v:
Molecular cell. 13(3)
The protein-tyrosine phosphatase Shp2 plays an essential role in growth factor and integrin signaling, and Shp2 mutations cause developmental defects and/or malignancy. Previous work has placed Shp2 upstream of Ras. However, the mechanism of Shp2 act