Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Marcelo G. Kazanietz, Jiansong Luo, Mark A. Lemmon, HongBin Wang, John M. Busillo, Maria Soledad Sosa, Cynthia Lopez-Haber, J. Silvio Gutkind, Ramon Parsons, Andres J. Klein-Szanto, Jeffrey L. Benovic, Chengfeng Yang, Hiroshi Yagi
Publikováno v:
Molecular Cell. 40:877-892
While the small GTPase Rac1 and its effectors are well-established mediators of mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in breast tumorigenesis, little is known regarding the exchange factors (Rac-GEFs) th
Autor:
Olena Barbash, Douglas I. Lin, J. Wade Harper, Anil K. Rustgi, Jason D. Weber, Serge Y. Fuchs, J. Alan Diehl, Andres J. Klein-Szanto, K.G. Suresh Kumar
Publikováno v:
Molecular Cell. 24(3):355-366
Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis. Degradation is triggered by threonine 286 phosphorylation, which promotes its ubiquitination by an unknown E3 ligase.