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Publikováno v:
Mol Cell
Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides produced by interrupted translation. Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, wh
Autor:
Rachel Patton McCord, Mikko Taipale, Sarah Teichmann, Rebecca M. Voorhees, Yue Wan, Cees Dekker, Neville E. Sanjana
Publikováno v:
Molecular cell. 82(2)
With the focus on technology for this issue of Molecular Cell, a group of scientists working in different areas of molecular biology provide their perspective on the most recent important technological advance in their field, where the field is lacki
Autor:
Grace A. Hernandez, Rushika M. Perera
Publikováno v:
Mol Cell
Molecular cell, vol 82, iss 8
Molecular cell, vol 82, iss 8
As one of the two highly conserved cellular degradation systems, autophagy plays a critical role in regulation of protein, lipid, and organelle quality control and cellular homeostasis. This evolutionarily conserved pathway singles out intracellular
Autor:
Marion E. Pesenti, Tobias Raisch, Duccio Conti, Kai Walstein, Ingrid Hoffmann, Dorothee Vogt, Daniel Prumbaum, Ingrid R. Vetter, Stefan Raunser, Andrea Musacchio
Publikováno v:
Molecular cell. 82(11)
Centromeres are specialized chromosome loci that seed the kinetochore, a large protein complex that effects chromosome segregation. A 16-subunit complex, the constitutive centromere associated network (CCAN), connects between the specialized centrome
Publikováno v:
Molecular Cell
Mol. Cell 82, 728-740 (2022)
Mol Cell
Mol. Cell 82, 728-740 (2022)
Mol Cell
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals. This cell death modality has been detected acro
Autor:
Shovamayee Maharana, Stefanie Kretschmer, Susan Hunger, Xiao Yan, David Kuster, Sofia Traikov, Thomas Zillinger, Marc Gentzel, Nagaraja Chappidi, Nadja Lucas, Katharina Isabell Maser, Henrike Maatz, Alexander Rapp, Virginie Marchand, K. Venkatesan Iyer, Akshita Chhabra, Young-Tae Chang, Yuri Motorin, Norbert Hubner, Gunther Hartmann, Anthony Hyman, Simon Alberti, Min Ae Lee-Kirsch
Publikováno v:
Molecular cell. 82(19)
Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense. This requires discrimination between structurally highly similar self and nonself nucleic acids to avoid aberrant inflammatory responses as in the autoinflamma
Autor:
Joshua J. Coon, M. Dal Peraro, Katherine A. Overmyer, A. S. Frost, M. Manicki, D. J. Pagliarini, Luciano A. Abriata, R. M. Guerra, H. Aydin
Publikováno v:
Molecular cell. 82(22)
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined ‘complex Q’ metabolon. Here we present a structure and
Autor:
Nicholas W. Hughes, Yuanhao Qu, Jiaqi Zhang, Weijing Tang, Justin Pierce, Chengkun Wang, Aditi Agrawal, Maurizio Morri, Norma Neff, Monte M. Winslow, Mengdi Wang, Le Cong
Publikováno v:
Molecular cell. 82(16)
The development of CRISPR-based barcoding methods creates an exciting opportunity to understand cellular phylogenies. We present a compact, tunable, high-capacity Cas12a barcoding system called dual acting inverted site array (DAISY). We combined hig
Autor:
Theodore Addo, Lakeya McGill, Jessica Silva-Fisher, Dominique Brooks, Josiane Joseph, Amaliris Guerra
Publikováno v:
Molecular Cell. 81:1355-1357
As part of our commitment to amplifying the voices of underrepresented scientists, we are publishing the insights and experiences of a panel of underrepresented scientists. In this piece, they discuss ways to make science more inclusive-from key poin
Publikováno v:
Mol Cell
Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, re