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Autor:
James E. Haber
Publikováno v:
Molecular cell. 82(13)
Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are c
Autor:
Benedict G. Tan, Christian D. Mutti, Yonghong Shi, Xie Xie, Xuefeng Zhu, Pedro Silva-Pinheiro, Katja E. Menger, Héctor Díaz-Maldonado, Wei Wei, Thomas J. Nicholls, Patrick F. Chinnery, Michal Minczuk, Maria Falkenberg, Claes M. Gustafsson
Publikováno v:
Molecular cell. 82(19)
The human mitochondrial genome must be replicated and expressed in a timely manner to maintain energy metabolism and supply cells with adequate levels of adenosine triphosphate. Central to this process is the idea that replication primers and gene pr
Publikováno v:
Molecular cell. 82(19)
The research article describing the discovery of ribosomal frameshifting in the bacterial CopA gene also reported the occurrence of frameshifting in the expression of the human ortholog ATP7B based on assays using dual luciferase reporters. An examin
Autor:
Swati Mohapatra, George A. Calin
Publikováno v:
Molecular Cell. 81:4349-4351
Sun et al. (2021) identified a novel translation initiation mechanism mediated through a new type of regulator named APPLE, a small peptide produced from a non-coding RNA transcript in acute myeloid leukemia, providing unforeseen opportunities for ta
Autor:
Qianxin Wu, Junjing Wu, Kaiser Karim, Xi Chen, Tengyao Wang, Sho Iwama, Stefania Carobbio, Peter Keen, Antonio Vidal-Puig, Mark R. Kotter, Andrew Bassett
Publikováno v:
Molecular Cell. 83:1125-1139.e8
CRISPR activation (CRISPRa) is an important tool to perturb transcription, but its effectiveness varies between target genes. We employ human pluripotent stem cells with thousands of randomly integrated barcoded reporters to assess epigenetic feature
Autor:
Georg E. Winter, Martin G. Jaeger
Publikováno v:
Molecular Cell. 81:1617-1630
Multi-dimensional omics profiling continues to illuminate the complexity of cellular processes. Because of difficult mechanistic interpretation of phenotypes induced by slow perturbation, fast experimental setups are increasingly used to dissect caus
Autor:
Seychelle M. Vos
Publikováno v:
Prof. Seychelle Vos
The influence of genome organization on transcription is central to our understanding of cell type specification. Higher-order genome organization is established through short- and long-range DNA interactions. Coordination of these interactions, from
Autor:
Karole N. D’Orazio, Rachel Green
Publikováno v:
Mol Cell
Eukaryotic cells integrate multiple quality control (QC) responses during protein synthesis in the cytoplasm. These QC responses are signaled by slow or stalled elongating ribosomes. Depending on the nature of the delay, the signal may lead to transl
Autor:
Josiane Joseph, Lathiena Manning Nervo, Amaliris Guerra, Marquis Walker, Francis Ayombil, Theodore Addo, Jessica Silva-Fisher, Lakeya McGill
Publikováno v:
Molecular Cell. 81:885-888
As part of our commitment to amplifying the voices of underrepresented scientists, we are publishing the insights and experiences of a panel of underrepresented scientists. In this segment, we asked about support systems-the types of support that are
Publikováno v:
Mol Cell
Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous and exogenous sources. Specialized DNA replication stress response pathways ensure replication fork progression in the presence of DNA lesions with minimal delay