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Autor:
Elijah Trefts, Reuben J. Shaw
Publikováno v:
Mol Cell
The evolution of AMPK and its homologs enabled exquisite responsivity and control of cellular energetic homeostasis. Recent work has been critical in establishing the mechanisms that determine AMPK activity, novel targets of AMPK action, and the dist
Autor:
Claudia Lennicke, Helena M. Cochemé
Publikováno v:
Molecular Cell. 81:3691-3707
Summary Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes are indispensable for organismal physiology and life itself. The term reactive oxygen species (ROS) describes a set of distinct molecular oxygen derivat
Autor:
Zhengming Wu, Kun-Liang Guan
Publikováno v:
Molecular cell. 82(22)
Using multi-omics approaches, Park et al. show that reduced cellular acetyl-CoA and protein hypoacetylation promote liver cancer growth and dedifferentiation.
Autor:
Filip Nemčko, Alexander Stark
Publikováno v:
Molecular Cell. 82:497-499
In this issue of Molecular Cell, Alerasool et al. (2022) present a proteome-scale functional screen to systematically uncover human proteins that can activate transcription.
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Autor:
Zhiyong Lou, Noam Stern-Ginossar, Sara Cherry, Craig E. Cameron, Thirumala-Devi Kanneganti, Jonathan Abraham, Laura Martin-Sancho
Publikováno v:
Molecular Cell
COVID-19 altered our lives and pushed scientific research to operate at breakneck speed, leading to significant breakthroughs in record time. We asked experts in the field about the challenges they faced in transitioning, rapidly but safely, to worki
Autor:
Marius K. Lemberg, Kvido Strisovsky
Publikováno v:
Molecular Cell. 81:2507-2519
Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degrad
Autor:
Yichen Xu, Davide Ruggero
Publikováno v:
Molecular cell. 82(14)
In this issue of Molecular Cell, Liu et al. (2022) report that 5'-tRF
Publikováno v:
Molecular cell. 82(23)
Neurotransmission mediated by diverse subtypes of N-methyl-D-aspartate receptors (NMDARs) is fundamental for basic brain functions and development as well as neuropsychiatric diseases and disorders. NMDARs are glycine- and glutamate-gated ion channel
Publikováno v:
Molecular cell. 82(13)
Vibert et al. (2022) demonstrate that oncogenic transcription factor fusion proteins bind otherwise silent genomic regions, producing RNAs that can be spliced, exported, and translated. These "neogenes" represent possible targets for immunotherapy an