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Autor:
Helen R. Saibil
Publikováno v:
Molecular Cell. 82:274-284
This review summarizes the current state of methods and results achievable by cryo-electron microscopy (cryo-EM) imaging for molecular, cell, and structural biologists who wish to understand what is required and how it might help to address their res
Publikováno v:
Molecular Cell. 82:241-247
Quantitative optical microscopy-an emerging, transformative approach to single-cell biology-has seen dramatic methodological advancements over the past few years. However, its impact has been hampered by challenges in the areas of data generation, ma
Publikováno v:
Mol Cell
Since its initial demonstration in 2000, far-field super-resolution light microscopy has undergone tremendous technological developments. In parallel, these developments have opened a new window into visualizing the inner life of cells at unprecedent
Publikováno v:
Molecular Cell. 82:304-314
Owing to their unique abilities to manipulate, label, and image individual molecules in vitro and in cellulo, single-molecule techniques provide previously unattainable access to elementary biological processes. In imaging, single-molecule fluorescen
Autor:
Christopher Jackson, Christine Vogel
Publikováno v:
Mol Cell
While measurements of RNA expression have dominated the world of single-cell analyses, new single-cell techniques increasingly allow collection of different data modalities, measuring different molecules, structural connections, and intermolecular in
Publikováno v:
Mol Cell
RNA binding proteins (RBPs) regulate nearly all post-transcriptional processes within cells. To fully understand RBP function, it is essential to identify their in vivo targets. Standard techniques for profiling RBP targets, such as crosslinking immu
Publikováno v:
Mol Cell
Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen infection. However, cancer cell pyroptosis (CCP) was recently discovered to be activated by
Publikováno v:
Molecular Cell. 81:3760-3774
The growing field of tumor metabolism has greatly expanded our knowledge of metabolic reprogramming in cancer. Apart from their established roles, various metabolic enzymes and metabolites harbor non-canonical ("moonlighting") functions to support ma
Publikováno v:
Mol Cell
Summary Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions remain as to which lipid species maintain metabolic homeostasis and which disrupt essent
Publikováno v:
Mol Cell
With the elucidation of a myriad anabolic and catabolic enzyme-catalyzed cellular pathways crisscrossing each other, an obvious question arose – how could these networks operate with maximal catalytic efficiency and minimal interference? A logical