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Autor:
Yannick Audet-Delage, Julie St-Pierre
Publikováno v:
Mol Cell
In tumors, nutrient availability and metabolism are known to be important modulators of growth signaling. However, it remains elusive whether cancer cells that are growing out in the metastatic niche rely on the same nutrients and metabolic pathways
Publikováno v:
Molecular cell. 82(1)
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in sever
Autor:
Evgeny Deforzh, Erik J. Uhlmann, Eashita Das, Aleksandra Galitsyna, Ramil Arora, Harini Saravanan, Rosalia Rabinovsky, Aditya D. Wirawan, Nadiya M. Teplyuk, Rachid El Fatimy, Sucika Perumalla, Anirudh Jairam, Zhiyun Wei, Leonid Mirny, Anna M. Krichevsky
Publikováno v:
Mol Cell
miR-10b is silenced in normal neuroglial cells of the brain but commonly activated in glioma, where it assumes an essential tumor-promoting role. We demonstrate that the entire miR-10b-hosting HOXD locus is activated in glioma via the cis-acting mech
Autor:
Mathieu Rougemaille, Jingjing Sun, Alicia Nevers, Denis L. J. Lafontaine, Valérie Migeot, Maxime Wery, Ludivine Wacheul, Peter C. Dedon, Felix G.M. Ernst, Carlo Yague-Sanz, Lara Katharina Krüger, Damien Hermand, Olivier Finet, Max Louski, Phong Tran, Antonin Morillon
Publikováno v:
Mol Cell
The epitranscriptome has emerged as a new fundamental layer of control of gene expression. Nevertheless, the determination of the transcriptome-wide occupancy and function of RNA modifications remains challenging. Here we have developed Rho-seq, an i
Autor:
Luis F. Soto, Zhaorong Li, Clarissa S. Santoso, Anna Berenson, Isabella Ho, Vivian X. Shen, Samson Yuan, Juan I. Fuxman Bass
Publikováno v:
Mol Cell
Transcription factors (TFs) regulate gene expression by binding to DNA sequences and modulating transcriptional activity through their effector domains. Despite the central role of effector domains in TF function, there is a current lack of a compreh
Autor:
Chong Zhang, Dongpeng Wang, Yajing Hao, Shuheng Wu, Jianjun Luo, Yuanchao Xue, Di Wang, Guohong Li, Lihui Liu, Changwei Shao, Huiyan Li, Jinfeng Yuan, Maoxiang Zhu, Xiang-Dong Fu, Xiao Yang, Runsheng Chen, Yan Teng
Publikováno v:
Molecular cell. 82(21)
Kinetochore assembly on centromeres is central for chromosome segregation, and defects in this process cause mitotic errors and aneuploidy. Besides the well-established protein network, emerging evidence suggests the involvement of regulatory RNA in
Autor:
Elphège P. Nora, Rini Shah
Publikováno v:
Mol Cell
The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin complexes from which the
Publikováno v:
Mol Cell
Cullin-RING E3 ligases (CRLs) are essential ubiquitylation enzymes that combine a catalytic core built around cullin scaffolds with ~300 exchangeable substrate adaptors. To ensure robust signal transduction, cells must constantly form new CRLs by pai
Autor:
Linhan Wang, Jiqiang Li, Qingchen Wang, Man-Xi Ge, Jia Ji, Di Liu, Zhiyuan Wang, Yang Cao, Yaoyang Zhang, Zai-Rong Zhang
Publikováno v:
Molecular cell. 82(18)
Membrane protein clients of endoplasmic reticulum (ER)-associated degradation must be retrotranslocated from the ER membrane by the AAA-ATPase p97 for proteasomal degradation. Before direct engagement with p97, client transmembrane domains (TMDs) tha
Autor:
Stéphane Richard, Jian Xu
Publikováno v:
Mol Cell
Arginine methylation is an influential post-translational modification occurring on histones, RNA binding proteins and many other cellular proteins affecting their function by altering their protein-protein and protein-nucleic acid interactions. Rece