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Autor:
Seychelle M. Vos
Publikováno v:
Prof. Seychelle Vos
The influence of genome organization on transcription is central to our understanding of cell type specification. Higher-order genome organization is established through short- and long-range DNA interactions. Coordination of these interactions, from
Publikováno v:
Mol Cell
Transcription is epigenetically regulated by the orchestrated function of chromatin-binding proteins that tightly control the expression of master transcription factors, effectors, and supportive housekeeping genes required for establishing and propa
Autor:
Mathieu Rougemaille, Jingjing Sun, Alicia Nevers, Denis L. J. Lafontaine, Valérie Migeot, Maxime Wery, Ludivine Wacheul, Peter C. Dedon, Felix G.M. Ernst, Carlo Yague-Sanz, Lara Katharina Krüger, Damien Hermand, Olivier Finet, Max Louski, Phong Tran, Antonin Morillon
Publikováno v:
Mol Cell
The epitranscriptome has emerged as a new fundamental layer of control of gene expression. Nevertheless, the determination of the transcriptome-wide occupancy and function of RNA modifications remains challenging. Here we have developed Rho-seq, an i
Autor:
Elphège P. Nora, Rini Shah
Publikováno v:
Mol Cell
The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin complexes from which the
Autor:
Stéphane Richard, Jian Xu
Publikováno v:
Mol Cell
Arginine methylation is an influential post-translational modification occurring on histones, RNA binding proteins and many other cellular proteins affecting their function by altering their protein-protein and protein-nucleic acid interactions. Rece
Publikováno v:
Molecular cell. 81(21)
Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system
Autor:
Henning Urlaub, Seychelle M. Vos, Christian Dienemann, Patrick Cramer, Ying Chen, Momchil Ninov
Publikováno v:
Molecular cell. 81(16)
Summary The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here, we report the cryoelectron microscopy (cryo-EM
Publikováno v:
Molecular Cell. 72:920-924
Fine tuning of the transcriptional program requires the competing action of multiple protein complexes in a well-organized environment. Genome folding creates proximity between genes, leading to accumulation of regulatory factors and formation of loc
Autor:
Nazaret Reverón-Gómez, Massimo Carraro, Yanhong Liu, Liu Chen, Hongyu Bao, Alberto García-Nieto, Colin Hammond, Ivo A. Hendriks, Hongda Huang, Christos Spanos, Michael L. Nielsen, Dinshaw J. Patel, Anja Groth, Juri Rappsilber
Publikováno v:
Molecular Cell
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548.e9 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548.e9 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548 . https://doi.org/10.1016/j.molcel.2021.03.041
Summary From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone
Autor:
Friedemann Weber, Jonathan Price, Eric A. Miska, Omer Ziv, Lyudmila A. Shalamova, Tsveta Kamenova, Ian Goodfellow
Publikováno v:
Molecular Cell
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA genomes in nature, coronaviruses are critically dependent on long-distance RN