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Autor:
Marie-Michelle Genois, Jian Ouyang, Hai Dang Nguyen, Dominick A. Matos, Jia Min Zhang, Lee Zou
Publikováno v:
Mol Cell
R loops arising during transcription induce genomic instability, but how cells respond to the R loop-associated genomic stress is still poorly understood. Here, we show that cells harboring high levels of R loops rely on the ATR kinase for survival.
Autor:
Harrison W. Gabel, J. Russell Moore, Guoyan Zhao, Adam W. Clemens, Dennis Y. Wu, Diana L. Christian
Publikováno v:
Mol Cell
The genomes of mammalian neurons contain uniquely high levels of non-CG DNA methylation that can be bound by the Rett syndrome protein, MeCP2, to regulate gene expression. How patterns of non-CG methylation are established in neurons and the mechanis
Autor:
Run-Wen Yao, Yang Wang, Guang Xu, Yu-Hang Xing, Ying Wang, Ling-Ling Chen, Li Yang, Man Wu, Peng-Fei Luan, Liang-Zhong Yang, Lin Shan
Publikováno v:
Molecular Cell. 76:767-783.e11
Fibrillar centers (FCs) and dense fibrillar components (DFCs) are essential morphologically distinct sub-regions of mammalian cell nucleoli for rDNA transcription and pre-rRNA processing. Here, we report that a human nucleolus consists of several doz
Autor:
Peng-Fei Luan, Gordon G. Carmichael, Run-Wen Yao, Siqi Li, Liang-Zhong Yang, Yang Wang, Huang Wu, Ling-Ling Chen
Publikováno v:
Molecular Cell. 76:981-997.e7
Visualizing the location and dynamics of RNAs in live cells is key to understanding their function. Here, we identify two endonuclease-deficient, single-component programmable RNA-guided and RNA-targeting Cas13 RNases (dCas13s) that allow robust real
Autor:
Golnaz Vahedi, Maxwell R. Mumbach, Shawn C. Little, Naomi Goldman, Yeqiao Zhou, Jon C. Aster, Stephen C. Blacklow, Zachary Zapataro, Warren S. Pear, Jelena Petrovic, Kelly S. Rome, Gregory W. Schwartz, Yogev Sela, Maria Fasolino, Michael J. Kruhlak, Eric F. Joyce, Son C. Nguyen, Junwei Shi, Robert B. Faryabi
Publikováno v:
Molecular cell. 73(6)
Chromatin loops enable transcription factor-bound distal enhancers to interact with their target promoters to regulate transcriptional programs. Although developmental transcription factors, such as active forms of Notch, can directly stimulate trans
Autor:
Ruslan Medzhitov, Scott D. Pope
Publikováno v:
Molecular cell. 71(3)
Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories
Autor:
W. Lee Kraus, Sridevi Challa, Dae Seok Kim, Venkat S. Malladi, Cristel V. Camacho, Anusha Nagari
Publikováno v:
Molecular Cell. 75:1270-1285.e14
PARP inhibitors (PARPi) prevent cancer cell growth by inducing synthetic lethality with DNA repair defects (e.g., in BRCA1/2 mutant cells). We have identified an alternative pathway for PARPi-mediated growth control in BRCA1/2-intact breast cancer ce
Autor:
François Le Dily, Narcis Fernandez Fuentes, Miguel Beato, Javier Quilez, Jose Carbonell Caballero, Dirk Eick, Priyanka Sharma, Chiara Di Vona, Roni H. G. Wright, Baldomero Oliva, Antonios Lioutas, Roland Schüller
Publikováno v:
Mol. Cell 73, 84-96 (2018)
HighlightsPeptidyl arginine deiminase 2 (PADI2) citrullinates arginine1810 (cit1810) present at carboxy-terminal domain of RNA polymerase II (RNAP2-CTD).PADI2 and R1810 of RNAP2-CTD regulate transcription and proliferation of breast cancer cells.Abse
Publikováno v:
Molecular cell. 73(1)
Summary In addition to phosphodiester bond formation, RNA polymerase II has an RNA endonuclease activity, stimulated by TFIIS, which rescues complexes that have arrested and backtracked. How TFIIS affects transcription under normal conditions is poor
Autor:
Joha Park, Myeong-Gyun Kang, Minjeong Kang, Baekgyu Kim, Min A. Kim, Hyun-Woo Rhee, V. Narry Kim, Yoosik Kim, Sujin Kim, Chulhwan Kwak
Publikováno v:
Molecular cell. 71(6)
Summary Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be activated by endogenously expressed dsRNAs. Here, we capture these dsRNAs by fo