Zobrazeno 1 - 10
of 549
pro vyhledávání: ''
Autor:
Eunus S. Ali, Anna Lipońska, Brendan P. O’Hara, David R. Amici, Michael D. Torno, Peng Gao, John M. Asara, Mee-Ngan F. Yap, Marc L. Mendillo, Issam Ben-Sahra
Publikováno v:
Molecular cell. 82(17)
Bicarbonate (HCO
Publikováno v:
Mol Cell
Molecular cell, vol 80, iss 2
Molecular cell, vol 80, iss 2
The Cdk-Rb-E2F pathway integrates external and internal signals to control progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway are found in most human cancers, and specific cyclin-dependent kinase Cdk4/6 inhibi
Autor:
Sixian Qi, Yuwen Zhu, Xincheng Liu, Pengyue Li, Yebin Wang, Yan Zeng, Aijuan Yu, Yu Wang, Zhao Sha, Zhenxing Zhong, Rui Zhu, Haixin Yuan, Dan Ye, Shenglin Huang, Chen Ling, Yanhui Xu, Dawang Zhou, Lei Zhang, Fa-Xing Yu
Publikováno v:
Molecular cell. 82(10)
YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are frequently activated in human cancers. The activity of YAP/TAZ is strictly repressed upon phosphorylation by LATS1/2 tumor suppressors. However, it is unclear how LATS1/2
Publikováno v:
Molecular cell. 81(21)
Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system
Autor:
Ina Huppertz, Joel I. Perez-Perri, Panagiotis Mantas, Thileepan Sekaran, Thomas Schwarzl, Francesco Russo, Dunja Ferring-Appel, Zuzana Koskova, Lyudmila Dimitrova-Paternoga, Eleni Kafkia, Janosch Hennig, Pierre A. Neveu, Kiran Patil, Matthias W. Hentze
Publikováno v:
Mol Cell
Huppertz, I, Perez-Perri, J I, Mantas, P, Sekaran, T, Schwarzl, T, Russo, F, Ferring-Appel, D, Koskova, Z, Dimitrova-Paternoga, L, Kafkia, E, Hennig, J, Neveu, P A, Patil, K & Hentze, M W 2022, ' Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation ', Molecular Cell, vol. 82, no. 14, pp. 2666-2680.e11 . https://doi.org/10.1016/j.molcel.2022.05.019
Huppertz, I, Perez-Perri, J I, Mantas, P, Sekaran, T, Schwarzl, T, Russo, F, Ferring-Appel, D, Koskova, Z, Dimitrova-Paternoga, L, Kafkia, E, Hennig, J, Neveu, P A, Patil, K & Hentze, M W 2022, ' Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation ', Molecular Cell, vol. 82, no. 14, pp. 2666-2680.e11 . https://doi.org/10.1016/j.molcel.2022.05.019
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we report that the cat-alytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly regulated by RNAs leading to metabolic rewiring in mouse embryonic s
Publikováno v:
Mol Cell
Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently, how polyamines are transported across membranes is not understood. Recent studies have suggested that ATP13A2 and its close homologs, collect
Autor:
Thomas R. Cotton, Simon A. Cobbold, Jonathan P. Bernardini, Lachlan W. Richardson, Xiangyi S. Wang, Bernhard C. Lechtenberg
Publikováno v:
Molecular Cell. 82:598-615.e8
An increasing number of genetic diseases are linked to deregulation of E3 ubiquitin ligases. Loss-of-function mutations in the RING-between-RING (RBR) family E3 ligase RNF216 (TRIAD3) cause Gordon-Holmes syndrome (GHS) and related neurodegenerative d
Publikováno v:
Molecular Cell. 82:527-541.e7
Citrulline can be converted into argininosuccinate by argininosuccinate synthetase (ASS1) in the urea cycle and the citrulline-nitric oxide cycle. However, the regulation and biological function of citrulline metabolism remain obscure in the immune s
Autor:
Rebecca Caeser, Triparna Sen
Publikováno v:
Mol Cell
While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A confers cellular resistance to CHK1 inhi
Publikováno v:
Molecular cell. 81(6)
In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play. However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift work are many and severe, including metabolic, mood, and malignant diso