Zobrazeno 91 - 100
of 549
pro vyhledávání: ''
Autor:
Weiwei Yang, Wencheng Zhu, Hua Yu, Ruilong Liu, Yajuan Zhang, Xiujuan Qu, Guohui Li, Wenfeng Li, Xiongjun Wang, Xueyuan Wu, Hong Gao, Ji Liang, Huiying Chu, Bangbao Tao
Publikováno v:
Molecular Cell. 76:148-162.e7
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Cancer cells often rewire their metabolic pathways for adaption to nutrient stress, and the underlying mechanism remains la
Autor:
Samuel E. I. Jones, Diana Bundschuh, Andrew N. Blackford, Daniel Fink, Mara De Marco Zompit, Ann-Marie K. Shorrocks, Laurence H. Pearl, Sarah Bonham, Roman Fischer, Pia-Amata Leimbacher, Manuel Stucki, Jordy Blaauwendraad, Matthew Day, Antony W. Oliver, Benedikt M. Kessler
Publikováno v:
Molecular cell. 74(3)
In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve genome stability. However, some early signaling events still occur, such as recruitment of the scaffold protein MDC1 to phosphorylated histone H2AX at DSBs. Yet, i
Autor:
Woo Seok Yang, Jane Melissa Lim, Yeonsil Kim, Jung-Soon Mo, In Young Lee, Hye Kyung Oh, Hyun Woo Park, Hyun Kyu Song, Hyunchu Cho, Je-Hyun Yoon, Kyung Hye Roh, Eunju Kim, Eui Ju Choi
Publikováno v:
Molecular cell. 73(6)
The nuclear factor (NF)-κB pathway plays a central role in inflammatory and immune responses, with aberrant activation of NF-κB signaling being implicated in various human disorders. Here, we show that mammalian ste20-like kinase 1 (MST1) is a prev
Autor:
Sagar Lonial, Jing Chen, Dong Chen, Lauren G. Zacharias, Qing Dai, Hieu Sy Vu, Ruiting Lin, Hui Mao, Yaozhu Pan, Christian M. Metallo, Shuangping Liu, Changliang Shan, Xue Gao, Titus J. Boggon, Yuancheng Li, Shaoxiong Wu, Ralph J. DeBerardinis, Esther W. Lim, Siyuan Xia, Liang Zhao, Mei Wang
Publikováno v:
Mol Cell
The oxidative pentose phosphate pathway (oxiPPP) contributes to cell metabolism through not only the production of metabolic intermediates and reductive NADPH, but also inhibition of LKB1-AMPK signaling by ribulose-5-phosphate (Ru-5-P), the product o
Autor:
John E. Burke
Publikováno v:
Molecular cell. 71(5)
Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's decision to grow, move, divide, and die. Because of this, kinases that phosphorylate phosphoinositide lipids are critically involved in myriad essential fu
Autor:
Joha Park, Myeong-Gyun Kang, Minjeong Kang, Baekgyu Kim, Min A. Kim, Hyun-Woo Rhee, V. Narry Kim, Yoosik Kim, Sujin Kim, Chulhwan Kwak
Publikováno v:
Molecular cell. 71(6)
Summary Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be activated by endogenously expressed dsRNAs. Here, we capture these dsRNAs by fo
Publikováno v:
Molecular cell. 69(4)
Inflammatory responses mediated by NOD2 rely on RIP2 kinase and ubiquitin ligase XIAP for the activation of nuclear factor κB (NF-κB), mitogen-activated protein kinases (MAPKs), and cytokine production. Herein, we demonstrate that selective XIAP an
Autor:
Leeanne McGurk, Van T. Tran, Robert G. Kalb, Nancy M. Bonini, Jelena Mojsilovic-Petrovic, Lin Guo, James Shorter, Edward Gomes
Publikováno v:
Molecular cell. 71(5)
Summary In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stress granule components, but how pathological TDP-43 aggregation is nucle
Autor:
Peter Liu, David A. Lawrence, Tsun-Kai Chang, Jenille Tan, Avi Ashkenazi, Jonathan M. Harnoss, Min Lu, Wendy Sandoval, Scot A. Marsters, Scott E. Martin
Publikováno v:
Molecular cell. 71(4)
The kinases PERK and IRE1 alleviate endoplasmic reticulum (ER) stress by orchestrating the unfolded protein response (UPR). If stress mitigation fails, PERK promotes cell death by activating pro-apoptotic genes, including death receptor 5 (DR5). Conv
Publikováno v:
Molecular cell
In this issue of Molecular Cell, Ying et al. (2018) report on a novel function of MLKL in sciatic nerve regeneration after injury through myelin sheath destabilization. This function of MLKL is independent of necroptosis execution and requires phosph