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Publikováno v:
Molecular Cell. 81:3246-3261.e11
Summary The Wnt/β-catenin pathway is a highly conserved, frequently mutated developmental and cancer pathway. Its output is defined mainly by β-catenin's phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the multi-
Autor:
Elizabeth Sassani, Beatrix Ueberheide, Linda Clijsters, John F. Dankert, David Fenyö, Michele Pagano, Phillip A. Geter, Keria Bermudez-Hernandez, Gergely Róna, Jeffrey R. Skaar, Robert J. Schneider
Publikováno v:
Molecular Cell. 64:507-519
SLBP (stem-loop binding protein) is a highly conserved factor necessary for the processing, translation, and degradation of H2AFX and canonical histone mRNAs. We identified the F-box protein cyclin F, a substrate recognition subunit of an SCF (Skp1-C
Autor:
Natalia Maverakis, Arnaldo A. Arbini, J Puccini, Patrick Sung, Youngho Kwon, Dafna Bar-Sagi, Michele Pagano, Antonio Marzio
Publikováno v:
Molecular cell. 73(2)
Summary The BRCA1-BRCA2-RAD51 axis is essential for homologous recombination repair (HRR) and is frequently disrupted in breast cancers. PARP inhibitors (PARPis) are used clinically to treat BRCA-mutated breast tumors. Using a genetic screen, we iden
Autor:
Li Quan, Xiaoyu Bai, Wei Peng, Yan Zhang, Xiuqin Zhang, Fengxiang Lv, Xinli Hu, Xianhua Wang, Kunlun Cheng, Rui-Ping Xiao, Dan Yang, Zhong Yu, Li Zhi, Lejiao Ren, Peng Jiang, Fengli Xu
Publikováno v:
Molecular Cell. 81:629-637.e5
As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon energy and glucose shortage but suppressed upon overnutrition. Exaggerated negative regulation of AMPK signaling by nutrient overload plays a crucial role in m
Autor:
Shiwei Ni, Suhong Yu, Xi Zhang, Yufeng Yang, Minhuang Hu, Zhenkun Zhang, Shujuan Wang, Jiexiang Huang, Yan Liu, M. Emdadul Haque, Jun Gao, Junxiang Li, Mingjuan Yang, Kai Chen, Ke Liu, Fei Chen, Xiaozhen Yang, Xiaohui Zhang, Yating Jiang, Yuexi Li, Caixi Gao, Guifeng Zhuang, Yuling Chen, Haiteng Deng, Jingjing Lin, Meina Ye, Li-Zhi Mi, Zhiliang Ji, Hai-Meng Zhou, Ling Sun, Wenfeng Chen, Yizhou Yao
Publikováno v:
Molecular Cell. 80:607-620.e12
Aberrant mitophagy has been implicated in a broad spectrum of disorders. PINK1, Parkin, and ubiquitin have pivotal roles in priming mitophagy. However, the entire regulatory landscape and the precise control mechanisms of mitophagy remain to be eluci
Autor:
Xinyi Tu, Ming Gao, Guijie Guo, Qian Zhu, Yusuke Kojima, Wootae Kim, Bo Qin, Qin Zhou, Ping Yin, Min Deng, Yong Zhang, Jinzhou Huang, Somaira Nowsheen, Yuichi J. Machida, Fei Zhao, Zhenkun Lou, Kuntian Luo
Publikováno v:
Mol Cell
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that threaten genomic integrity. Recent findings highlight that SPRTN, a specialized DNA-dependent metalloprotease, is a central player in proteolytic cleavage of DPCs. Previous studies sugge
Autor:
Knut Beuerlein, Julia Busch, Ulas Tenekeci, Christin Buro, Helmut Müller, Doris Newel, Zhijian J. Chen, Daniela Kettner-Buhrow, Ming Xu, Hendrik Weiser, Michael Kracht, Michael Poppe, Katharina Porada, M. Lienhard Schmitz
Publikováno v:
Molecular Cell. 62:943-957
Signals and posttranslational modifications regulating the decapping step in mRNA degradation pathways are poorly defined. In this study we reveal the importance of K63-linked ubiquitylation for the assembly of decapping factors, P-body formation, an
Autor:
Rekha Iyengar, Mondira Kundu, Junmin Peng, Lu Xu, Fusun Kilic, Xiu Jie Li-Harms, Tullia Lindsten, Anjon Audhya, Linda M. Hendershot, Douglas R. Green, Ji Ying Sze, Christopher Wright, Bo Wang, Timothy I. Shaw, E.B. Frankel, Joung Hyuck Joo, Liang Ge
Publikováno v:
Molecular Cell. 62:491-506
ULK1 and ULK2 are thought to be essential for initiating autophagy, and Ulk1/2-deficient mice die perinatally of autophagy-related defects. Therefore, we used a conditional knockout approach to investigate the roles of ULK1/2 in the brain. Although t
Publikováno v:
Molecular Cell. 61(3):419-433
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but the mechanism remains elusive. Here we show that FBXW7 facilitates nonhomologous end-joining
Autor:
Bo Qin, Xu Yang, Haoxing Zhang, Min Deng, Huadong Pei, Liewei Wang, Seung Baek Lee, Wei Guo, Jung Jin Kim, Jian Yuan, Zhenkun Lou, Tongzheng Liu
Publikováno v:
Molecular Cell. 61:614-624
The AMP-activated protein kinase (AMPK) is the master regulator of metabolic homeostasis by sensing cellular energy status. When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosph