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Autor:
Diego A. Rodriguez, Cliff Guy, Christy R. Grace, Amanda Nourse, Randall Wakefield, Fabien Llambi, Tudor Moldoveanu, Giovanni Quarato, Douglas R. Green, Sharon Frase
Publikováno v:
Molecular Cell. 61(4):589-601
Necroptosis is a cell death pathway regulated by the receptor interacting protein kinase 3 (RIPK3) and the mixed lineage kinase domain-like (MLKL) pseudokinase. How MLKL executes plasma membrane rupture upon phosphorylation by RIPK3 remains controver
Autor:
Kyle A. Nilson, Jiannan Guo, John E. Brogie, David H. Price, Michael E. Turek, Elizabeth Delaney, Donal S. Luse
Publikováno v:
Molecular Cell. 59(4):576-587
The Cdk7 subunit of TFIIH phosphorylates RNA polymerase II (Pol II) during initiation, and, while recent studies show that inhibition of human Cdk7 negatively influences transcription, the mechanisms involved are unclear. Using in vitro transcription
Autor:
David M. Smalley, Vishwajith Sridharan, Henrik G. Dohlman, Daniel G. Isom, Rachael Baker, Sarah T. Clement
Publikováno v:
Molecular Cell. 51:531-538
In response to environmental stress, cells often generate pH signals that serve to protect vital cellular components and reprogram gene expression for survival. A major barrier to our understanding of this process has been the identification of signa
Autor:
Xiaobo Nie, Dmitry Temiakov, Min Li, Sundararajan Venkatesh, Daniel F. Bogenhagen, Jae Lee, Carolyn K. Suzuki, Yaroslav I. Morozov, Bin Lu
Publikováno v:
Molecular Cell. 49(1):121-132
Human mitochondrial transcription factor A (TFAM) is a high-mobility group (HMG) protein at the nexus of mitochondrial DNA (mtDNA) replication, transcription, and inheritance. Little is known about the mechanisms underlying its posttranslational regu
Autor:
Jonathan Clark, Phillip T. Hawkins, Oscar Vadas, Olga Perisic, Roger L. Williams, Len R. Stephens, Karen E. Anderson, Xuxiao Zhang
Publikováno v:
Molecular Cell
Molecular cell
Molecular cell
Summary Phosphoinositide 3-kinases (PI3Ks) are essential for cell growth, migration, and survival. The structure of a p110β/p85β complex identifies an inhibitory function for the C-terminal SH2 domain (cSH2) of the p85 regulatory subunit. Mutagenes
Autor:
Carol X.-Q. Chen, Edward A. Fon, Guennadi Kozlov, Peter S. McPherson, Edna Camacho, Karl Grenier, Jean-François Trempe, Kalle Gehring
Publikováno v:
Molecular Cell. 36(6):1034-1047
Mutations in the parkin gene are responsible for a common inherited form of Parkinson's disease (PD). Parkin is a RING-type E3 ubiquitin ligase with an N-terminal ubiquitin-like domain (Ubl). We report here that the parkin Ubl binds SH3 domains from
Autor:
Zhongsheng You, John Brognard, Youwei Zhang, Chris Coughlin, Aaron Aslanian, Tony Hunter, Gerard Manning, Robert T. Abraham, Marisa Dolled-Filhart
Publikováno v:
Molecular Cell. 35:442-453
Central to the replication checkpoint are two protein kinases, ATR, and its downstream target kinase, Chk1. Signaling pathways leading to activation of ATR-Chk1 have been extensively investigated; however, events that mediate checkpoint termination a
Publikováno v:
Molecular Cell. 35(2):164-180
Glutamyl-prolyl tRNA synthetase (EPRS) is a component of the heterotetrameric gamma-interferon-activated inhibitor of translation (GAIT) complex that binds 3'UTR GAIT elements in multiple interferon-gamma (IFN-gamma)-inducible mRNAs and suppresses th
Autor:
Sung Hee Choi, Diego Alvarado, Monica Red Brewer, Graham Carpenter, Katarina Moravcevic, Ambra Pozzi, Mark A. Lemmon
Publikováno v:
Molecular Cell. 34(6):641-651
Summary In several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis and crystallographic approac
Publikováno v:
Molecular Cell. 33(2):181-191
The mixed-lineage leukemia protein MLL1 is a transcriptional regulator with an essential role in early development and hematopoiesis. The biological function of MLL1 is mediated by the histone H3K4 methyltransferase activity of the carboxyl-terminal