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Autor:
Michelle M, Mitchener, Tom W, Muir
Publikováno v:
Molecular Cell. 82:2925-2938
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now appreciated that somatic missense mutations in histones, the packaging agents of genomic DNA, are often associated with human pathologies, especially cancer. A
Autor:
Russell Spencer-Smith, Elizabeth M. Terrell, Christine Insinna, Constance Agamasu, Morgan E. Wagner, Daniel A. Ritt, Jim Stauffer, Andrew G. Stephen, Deborah K. Morrison
Publikováno v:
Molecular cell. 82(22)
BRAF is frequently mutated in human cancer and the RASopathy syndromes, with RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD participates in phosphatidylserine (PS) binding, the RAS-RAF interaction, and RAF auto
Autor:
Sven M. Lange, Syed Arif Abdul Rehman, Dmitri I. Svergun, Lee A. Armstrong, Yogesh Kulathu, Yosua Adi Kristariyanto, Axel Knebel, Tobias W. Gräwert
Publikováno v:
'Molecular Cell ', vol: 81, pages: 4176-4190 (2021)
Molecular cell 81, S1097276521006912 (1-15) (2021). doi:10.1016/j.molcel.2021.08.024
Molecular Cell
Molecular cell 81, S1097276521006912 (1-15) (2021). doi:10.1016/j.molcel.2021.08.024
Molecular Cell
Summary Of the eight distinct polyubiquitin (polyUb) linkages that can be assembled, the roles of K48-linked polyUb (K48-polyUb) are the most established, with K48-polyUb modified proteins being targeted for degradation. MINDY1 and MINDY2 are members
Autor:
Sophie M.-C. Gobeil, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, Esther Beaudoin, Kartik Manne, Dapeng Li, Rob Parks, Maggie Barr, Margaret Deyton, Mitchell Martin, Katayoun Mansouri, Robert J. Edwards, Amanda Eaton, David C. Montefiori, Gregory D. Sempowski, Kevin O. Saunders, Kevin Wiehe, Wilton Williams, Bette Korber, Barton F. Haynes, Priyamvada Acharya
Publikováno v:
Molecular cell. 82(11)
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor-binding domain (RBD) and neutralizing
Autor:
Luis F. Soto, Zhaorong Li, Clarissa S. Santoso, Anna Berenson, Isabella Ho, Vivian X. Shen, Samson Yuan, Juan I. Fuxman Bass
Publikováno v:
Mol Cell
Transcription factors (TFs) regulate gene expression by binding to DNA sequences and modulating transcriptional activity through their effector domains. Despite the central role of effector domains in TF function, there is a current lack of a compreh
Autor:
Dong Wang, Chenchen Xu, Wenyu Yang, Jie Chen, Yuhui Ou, Yuanyuan Guan, Jialiang Guan, Ying Liu
Publikováno v:
Molecular cell. 82(4)
The mTOR complex 1 (mTORC1) is an essential metabolic hub that coordinates cellular metabolism with the availability of nutrients, including amino acids. Sestrin2 has been identified as a cytosolic leucine sensor that transmits leucine status signals
Publikováno v:
Molecular cell. 81(21)
Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system
Autor:
Johannes Berlandi, Amel Chaouch, Brian Krug, Carol C.L. Chen, Chao Lu, Steven Hébert, Shireen Badini, Xiao Chen, Paul Lasko, Martin Hasselblatt, Felice Frey, Ashot S. Harutyunyan, Nada Jabado, Astrid Jeibmann, Claudia L. Kleinman, Margret Shirinian
Publikováno v:
Molecular cell. 81(23)
Summary Histone H3.3 lysine-to-methionine substitutions K27M and K36M impair the deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show that these mutations induce hypotrophic and disorganized eyes in Drosophila eye primordia.
Autor:
Yuehong Chen, Congying Pu, Minjia Tan, Zhiwei Liu, Fuchu He, Jing Li, Xiaomin Wang, Min Huang, Linhui Zhai, Shu Ye, Jun Xu, Shangwen Jiang, Xiameng Gai, Lili Qian, Yingluo Liu
Publikováno v:
Molecular cell. 81(19)
KRAS mutant cancer, characterized by the activation of a plethora of phosphorylation signaling pathways, remains a major challenge for cancer therapy. Despite recent advancements, a comprehensive profile of the proteome and phosphoproteome is lacking
Autor:
Ivan Ahel, Yan Yan, Baomin Feng, Jun Hyeok Kim, Ping He, Johannes Gregor Matthias Rack, Jyan-Chyun Jang, Ying Wang, Liang Kong, Libo Shan, Chao Zhang, Lahong Xu
Publikováno v:
Molecular cell. 81(22)
Protein ADP-ribosylation is a reversible post-translational modification that transfers ADP-ribose from NAD+ onto acceptor proteins. Poly(ADP-ribosyl)ation (PARylation), catalyzed by poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydr