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Autor:
Lara Wohlbold, Eugene Valkov, Cátia Igreja, Daniel Peter, Min Yi Chung, Oliver Weichenrieder, Elisa Izaurralde, S. Grüner, Ramona Weber
Publikováno v:
Molecular Cell. 64:467-479
Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This interaction is a major drug target for repressing translation and is naturally regulated by 4E-bi
Publikováno v:
Mol Cell
The mammalian pre-mRNA 3'-end-processing machinery consists of cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other proteins, but the overall architecture of this machinery remains unclear. CPSF contai
Publikováno v:
Molecular cell. 74(2)
In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-produc
Publikováno v:
Molecular Cell
Summary Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspo
Autor:
Pamelyn Woo, Javad Nazarian, Madhuri Kambhampati, Surya Nagaraja, James Lennon, Shawn M. Gillespie, Michelle Monje, Marlene Arzt, Michael Quezada, Mariella G. Filbin, Mario L. Suvà, Volker Hovestadt
Publikováno v:
Mol Cell
Development of effective targeted cancer therapies is fundamentally limited by our molecular understanding of disease pathogenesis. Diffuse intrinsic pontine glioma (DIPG) is a fatal malignancy of the childhood pons characterized by a unique substitu
Autor:
Paul C. Boutros, Michal Krassowski, Keren Isaev, Dike Aduluso-Nwaobasi, Irakli Dzneladze, Luyao Ruan, Lina Wadi, Yao Li, Jüri Reimand, Oliver Ocsenas, Diala Abd-Rabbo, Marta Paczkowska, Lincoln D. Stein, Liis Uusküla-Reimand, Helen He Zhu, Jared T. Simpson, J. Drew Thompson, Mathieu Lupien, Michael D. Wilson, Shimin Shuai, Minggao Liang, Vincent Huang, Azad Alizada
Publikováno v:
Molecular cell. 77(6)
A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide disco
Autor:
Peter Arvan, Billy Tsai, Corey N. Cunningham, Jeffrey M. Williams, Anoop Arunagiri, Jeffrey Knupp
Publikováno v:
Molecular cell. 75(3)
Insulin gene coding sequence mutations are known to cause mutant INS-gene-induced diabetes of youth (MIDY), yet the cellular pathways needed to prevent misfolded proinsulin accumulation remain incompletely understood. Here, we report that Akita mutan
Autor:
Daniel A. Ritt, Deborah K. Morrison, Yong Zhou, David E. Durrant, Elizabeth M. Terrell, Dominic Esposito, Russell Spencer-Smith, Robert L. Kortum, John F. Hancock, Erin Sheffels, Nancy E. Sealover
Publikováno v:
Molecular cell. 76(6)
The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of indiv
Publikováno v:
Molecular cell. 76(4)
Spt5 is a conserved and essential transcription elongation factor that promotes promoter-proximal pausing, promoter escape, elongation, and mRNA processing. Spt5 plays specific roles in the transcription of inflammation and stress-induced genes and t
Autor:
Carlos Oscar S. Sorzano, Mario Mellado, Juan A. Torreno-Pina, Rubén Barroso, Carlo Manzo, César Santiago, Maria F. Garcia-Parajo, Laura Martínez-Muñoz, Laura Barrio, Graciela Cascio, José Miguel Rodríguez-Frade, Pilar de Lucas, Yolanda R. Carrasco, Eva M. García-Cuesta, Enric Gutierrez, Javier Vargas, Francisco Sánchez-Madrid
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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A current challenge in cell motility studies is to understand the molecular and physical mechanisms that govern chemokine receptor nanoscale organization at the cell membrane, and their influence on cell response. Using single-particle tracking and s