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Autor:
Luis F. Soto, Zhaorong Li, Clarissa S. Santoso, Anna Berenson, Isabella Ho, Vivian X. Shen, Samson Yuan, Juan I. Fuxman Bass
Publikováno v:
Mol Cell
Transcription factors (TFs) regulate gene expression by binding to DNA sequences and modulating transcriptional activity through their effector domains. Despite the central role of effector domains in TF function, there is a current lack of a compreh
Publikováno v:
Molecular cell. 81(21)
Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system
Autor:
Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on global public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nu
Publikováno v:
Molecular cell. 76(4)
Spt5 is a conserved and essential transcription elongation factor that promotes promoter-proximal pausing, promoter escape, elongation, and mRNA processing. Spt5 plays specific roles in the transcription of inflammation and stress-induced genes and t
Autor:
Christopher C. Ebmeier, Steven Hahn, Vishnu Raman, Andrej Sali, Bong Yoon Kim, Dylan J. Taatjes, Peter Cimermancic, Jie Luo, Charles H. Greenberg, Riccardo Pellarin, Shruthi Viswanath, Jeff Ranish, Marine Dehecq
Publikováno v:
Molecular cell, vol 59, iss 5
TFIIH is essential for both RNA polymerase II transcription and DNA repair, and mutations in TFIIH can result in human disease. Here, we determine the molecular architecture of human and yeast TFIIH by an integrative approach using chemical crosslink
Autor:
Bin Wang, Atanu Paul
Publikováno v:
Molecular cell. 66(4)
Ubiquitin modification of proteins plays pivotal roles in the cellular response to DNA damage. Given the complexity of ubiquitin conjugation due to the formation of poly-conjugates of different linkages, functional roles of linkage-specific ubiquitin
Autor:
Seo-Hee You, Mitchell A. Lazar, Christopher S. Nabel, Bin Fang, Kyoung-Jae Won, Zheng Sun, Dan Feng, Shannon E. Mullican, Vignesh Selvakumaran, Hee-Woong Lim, Logan J. Everett, Yun Li
Publikováno v:
Molecular Cell. 52(6):769-782
Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severe hepatosteatosis. Here we show that pharmacologic HDAC inh
Autor:
Jorge Cuéllar, Patricia A.J. Muller, Karen H. Vousden, José M. Valpuesta, Marta Klejnot, Max Nobis, Antonio García Trinidad
Publikováno v:
Molecular Cell
Summary p53 is a transcription factor that mediates tumor suppressor responses. Correct folding of the p53 protein is essential for these activities, and point mutations that induce conformational instability of p53 are frequently found in cancers. T
Autor:
Jean-Marc Egly, Sergey Alekseev, Jérémy Sandoz, Amélie Weiss, Frédéric Coin, Zita Nagy, Nicolas Le May
Publikováno v:
Molecular Cell
Molecular Cell, 2017, 65 (3), pp.504-514.e4. ⟨10.1016/j.molcel.2017.01.012⟩
Molecular Cell, 2017, 65 (3), pp.504-514.e4. ⟨10.1016/j.molcel.2017.01.012⟩
International audience; Transcription starts with the assembly of pre-initiation complexes on promoters followed by their opening. Current models suggest that class II gene transcription requires ATP and the TFIIH XPB subunit to open a promoter. Here
Autor:
Dan Zhao, Benjamin R. Sabari, Tatyana Panchenko, Yuanyuan Li, Xiaobing Shi, Yingming Zhao, Hong Wen, Robert G. Roeder, C. David Allis, He Huang, Haitao Li, Zhanyun Tang, Liling Wan, Haipeng Guan
Publikováno v:
Molecular cell. 62(2)
Recognition of histone covalent modifications by chromatin-binding protein modules (“readers”) constitutes a major mechanism for epigenetic regulation, typified by bromodomains that bind acetyllysine. Non-acetyl histone lysine acylations (e.g. cr