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Autor:
Kristina Wagner, Manuel Kaulich, Jan Keiten-Schmitz, Tanja Piller, Simon Alberti, Stefan Müller
Publikováno v:
Molecular cell. 79(1)
Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) systems. In response to proteotoxic stress, cells also limit prote
Autor:
Annie Moradian, Masami Hazu, Alina Guna, Rebecca M. Voorhees, Tino Pleiner, Kurt Januszyk, Robert S. Oania, Giovani P. Tomaleri, Michael J. Sweredoski
Publikováno v:
Mol Cell
The assembly of nascent proteins into multi-subunit complexes is a tightly regulated process which must occur at high fidelity to maintain cellular homeostasis. The ER membrane protein complex (EMC) is an essential insertase that requires seven membr
Autor:
Anna Thrun, Annarita Patrizi, Charles S. Umbaugh, Teresa Dallinger, Sylvia Kreger, Pratik R. Patil, Claudio A. P. Joazeiro, Jia Liu, Gregory A. Cox, Yu Kigoshi-Tansho, Aitor Garzia, Thomas Tuschl
Publikováno v:
Mol Cell
Summary Incompletely synthesized nascent chains obstructing large ribosomal subunits are targeted for degradation by ribosome-associated quality control (RQC). In bacterial RQC, RqcH marks the nascent chains with C-terminal alanine (Ala) tails that a
Publikováno v:
'Molecular Cell ', vol: 68, pages: 233-246 (2017)
Molecular Cell, 68 (1)
Molecular Cell
Molecular Cell, 68 (1)
Molecular Cell
Summary Several ubiquitin chain types have remained unstudied, mainly because tools and techniques to detect these posttranslational modifications are scarce. Linkage-specific antibodies have shaped our understanding of the roles and dynamics of poly
Autor:
Matthew M. Makowski, Michiel Vermeulen, Gabriëlle B. A. van Tilburg, Pascal W.T.C. Jansen, Xiaofei Zhang, Arne H. Smits, Huib Ovaa
Publikováno v:
Molecular Cell, 65(5), 941
Molecular Cell, 65, 941-955
Molecular Cell, 65, 5, pp. 941-955
Molecular Cell, 65, 941-955
Molecular Cell, 65, 5, pp. 941-955
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-
Autor:
Elizabeth Sassani, Beatrix Ueberheide, Linda Clijsters, John F. Dankert, David Fenyö, Michele Pagano, Phillip A. Geter, Keria Bermudez-Hernandez, Gergely Róna, Jeffrey R. Skaar, Robert J. Schneider
Publikováno v:
Molecular Cell. 64:507-519
SLBP (stem-loop binding protein) is a highly conserved factor necessary for the processing, translation, and degradation of H2AFX and canonical histone mRNAs. We identified the F-box protein cyclin F, a substrate recognition subunit of an SCF (Skp1-C
Autor:
Kyosuke Nakamura, Constance Alabert, Moritz Völker-Albert, Chunaram Choudhary, Shankha Satpathy, Axel Imhof, Georg Kustatscher, Niels Mailand, Ignasi Forné, Martina Hödl, Tracey E. Beyer, Anja Groth, Juri Rappsilber
Publikováno v:
Molecular Cell
Nakamura, K, Kustatscher, G, Alabert, C, Hödl, M, Forne, I, Völker-Albert, M, Satpathy, S, Beyer, T E, Mailand, N, Choudhary, C, Imhof, A, Rappsilber, J & Groth, A 2021, ' Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination ', Molecular Cell, vol. 81, no. 3 . https://doi.org/10.1016/j.molcel.2020.12.025
Nakamura, K, Kustatscher, G, Alabert, C, Hödl, M, Forne, I, Völker-Albert, M, Satpathy, S, Beyer, T E, Mailand, N, Choudhary, C, Imhof, A, Rappsilber, J & Groth, A 2021, ' Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination ', Molecular Cell, vol. 81, no. 5, pp. P1084-1099.E6 . https://doi.org/10.1016/j.molcel.2020.12.025
Nakamura, K, Kustatscher, G, Alabert, C, Hödl, M, Forne, I, Völker-Albert, M, Satpathy, S, Beyer, T E, Mailand, N, Choudhary, C, Imhof, A, Rappsilber, J & Groth, A 2021, ' Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination ', Molecular Cell, vol. 81, no. 3 . https://doi.org/10.1016/j.molcel.2020.12.025
Nakamura, K, Kustatscher, G, Alabert, C, Hödl, M, Forne, I, Völker-Albert, M, Satpathy, S, Beyer, T E, Mailand, N, Choudhary, C, Imhof, A, Rappsilber, J & Groth, A 2021, ' Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination ', Molecular Cell, vol. 81, no. 5, pp. P1084-1099.E6 . https://doi.org/10.1016/j.molcel.2020.12.025
Summary Cells have evolved an elaborate DNA repair network to ensure complete and accurate DNA replication. Defects in these repair machineries can fuel genome instability and drive carcinogenesis while creating vulnerabilities that may be exploited
Autor:
Shiwei Ni, Suhong Yu, Xi Zhang, Yufeng Yang, Minhuang Hu, Zhenkun Zhang, Shujuan Wang, Jiexiang Huang, Yan Liu, M. Emdadul Haque, Jun Gao, Junxiang Li, Mingjuan Yang, Kai Chen, Ke Liu, Fei Chen, Xiaozhen Yang, Xiaohui Zhang, Yating Jiang, Yuexi Li, Caixi Gao, Guifeng Zhuang, Yuling Chen, Haiteng Deng, Jingjing Lin, Meina Ye, Li-Zhi Mi, Zhiliang Ji, Hai-Meng Zhou, Ling Sun, Wenfeng Chen, Yizhou Yao
Publikováno v:
Molecular Cell. 80:607-620.e12
Aberrant mitophagy has been implicated in a broad spectrum of disorders. PINK1, Parkin, and ubiquitin have pivotal roles in priming mitophagy. However, the entire regulatory landscape and the precise control mechanisms of mitophagy remain to be eluci
Autor:
Ramanujan S. Hegde, Sichen Shao, Robert J. Keenan, Eisuke Itakura, Matthew L. Wohlever, Eszter Zavodszky
Publikováno v:
Molecular Cell
Summary We investigated how mitochondrial membrane proteins remain soluble in the cytosol until their delivery to mitochondria or degradation at the proteasome. We show that Ubiquilin family proteins bind transmembrane domains in the cytosol to preve
Autor:
Paul P. Geurink, Charlotte H. Durkin, Jonathan N. Pruneda, David W. Holden, Balaji Santhanam, Huib Ovaa, David Komander
Publikováno v:
Molecular Cell
'Molecular Cell ', vol: 63, pages: 261-276 (2016)
'Molecular Cell ', vol: 63, pages: 261-276 (2016)
Summary Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as