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Autor:
Rebecca Caeser, Triparna Sen
Publikováno v:
Mol Cell
While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A confers cellular resistance to CHK1 inhi
Publikováno v:
Molecular cell. 81(11)
The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 (mTORC1). To resolve the mechanism of this hierarchical phosphorylation at
Autor:
Carla Margulies, Andreas G. Ladurner
Publikováno v:
Mol Cell
Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD(+)-dependent ADP-ribosylation of histone H2B-Glu35 by snoRN
Autor:
Wanjun Zhang, Pei Jiang, Zhuqing Li, Xiangpan Li, Wei Tan, Wenge Zhu, Yi Yao, Weijie Qin, Changmin Peng, Aihua Sun, Qibin Song, Shaofeng Lin, Fuchu He, Yu Xue, Zhaohua Hu, Huadong Pei, Yali Chen, Yingge Li, Lulu Chen
Publikováno v:
Molecular Cell. 81:1890-1904.e7
O-linked β-N-acetyl glucosamine (O-GlcNAc) is attached to proteins under glucose-replete conditions; this posttranslational modification results in molecular and physiological changes that affect cell fate. Here we show that posttranslational modifi
Autor:
Jiechao Zhou, David J. Linden, Yang-An Chuang, Liuqing Yang, Paul F. Worley, Youn Na, Wenchi Zhang, Alena Savonenko, Zeng You Ye, Jing Wu, Daniel J. Leahy, Jessica Qiu, Richard L. Huganir, Raozhou Lin
Publikováno v:
Mol Cell
Arc is a synaptic protein essential for memory consolidation. Recent studies indicate that Arc originates in evolution from a Ty3-Gypsy retrotransposon GAG domain. The N-lobe of Arc GAG domain acquired a hydrophobic binding pocket in higher vertebrat
Publikováno v:
Molecular Cell. 62:397-408
Cofilin/actin-depolymerizing factor (ADF) proteins are critical nodes that relay signals from protein kinase cascades to the actin cytoskeleton, in particular through site-specific phosphorylation at residue Ser3. This is important for regulation of
Autor:
Julia Kamenz, James E. Ferrell
Publikováno v:
Molecular Cell, 65(3), 371-373. CELL PRESS
Cell-cycle phosphorylation is temporally ordered, at least in part, through the sequential expression of different cyclins. Recent studies by Swaffer et al. (2016) and Godfrey et al. (2017) show that intrinsic properties of the substrate proteins con
Autor:
Evgeny Zatulovskiy, Benjamin R. Topacio, Julien Sage, Shicong Xie, Jan M. Skotheim, Seth M. Rubin, Mardo Kõivomägi, Carrie S. Tambo, Sandra Cristea
Publikováno v:
Molecular cell. 74(4)
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by phosph
Autor:
Joha Park, Myeong-Gyun Kang, Minjeong Kang, Baekgyu Kim, Min A. Kim, Hyun-Woo Rhee, V. Narry Kim, Yoosik Kim, Sujin Kim, Chulhwan Kwak
Publikováno v:
Molecular cell. 71(6)
Summary Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be activated by endogenously expressed dsRNAs. Here, we capture these dsRNAs by fo
Publikováno v:
Molecular Cell. 73:446-457.e6
Multisite phosphorylation of kinases can induce on-off or graded regulation of catalytic activity; however, its influence on substrate specificity remains unclear. Here we show multisite phosphorylation of ribosomal protein S6 kinase 1 (S6K1) alters