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Autor:
Elphège P. Nora, Rini Shah
Publikováno v:
Mol Cell
The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin complexes from which the
Publikováno v:
Molecular Cell. 72:920-924
Fine tuning of the transcriptional program requires the competing action of multiple protein complexes in a well-organized environment. Genome folding creates proximity between genes, leading to accumulation of regulatory factors and formation of loc
Autor:
Maria Victoria Neguembor, Chao-ting Wu, Maria Pia Cosma, Chiara Vicario, Pablo Aurelio Gómez-García, Laura Martin, Álvaro Castells-García, Melike Lakadamyali, Francesco Sottile, Davide Carnevali, Jumana AlHaj Abed, Jérôme Solon, Ruben Sebastian-Perez, Alba Granados
Publikováno v:
Molecular cell. 81(15)
The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin complexes from which the
Autor:
Omid Gholamalamdari, Shawn C. Little, K.M.A. Tanim, Charly R. Good, Joan Lim, Andrew S. Belmont, Margaret C. Dunagin, Liguo Zhang, Katherine A. Alexander, Son C. Nguyen, Paula Agudelo-Garcia, Enrique Lin-Shiao, Allison Cote, Mariel R. Mendoza, Eric F. Joyce, Nicolas Biddle, Shelley L. Berger, Arjun Raj
Publikováno v:
Mol Cell
Nuclear speckles are prominent nuclear bodies that contain proteins and RNA involved in gene expression. While links between nuclear speckles and gene activation are emerging, the mechanisms regulating association of genes with speckles are unclear.
RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells
Autor:
Hui Zhou, Zhiquan Wang, Mats Ljungman, Tamas Ordog, Marc S. Wold, Honglian Zhang, Zhiguo Zhang, Haiyun Gan, Jeong Heon Lee
Publikováno v:
Molecular Cell. 65:272-284
The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through a short hairpin RNA (shR
Publikováno v:
Molecular cell. 73(3)
During transcription, the nascent RNA strand can base pair with its template DNA, displacing the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are common across many domains of life and cause DNA damage in certain con
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes
Autor:
Hong Shen, Michael A. Mancini, Bert W. O'Malley, Ping Yi, Zhao Wang, Muyuan Chen, Ross A. Hamilton, Charles E. Foulds, Xinzhe Yu, Steven J. Ludtke
Publikováno v:
Mol Cell
Steroid receptors activate gene transcription by recruiting coactivators to initiate transcription of their target genes. For most nuclear receptors, the ligand-dependent activation function domain-2 (AF-2) is a primary contributor to the nuclear rec
Autor:
Aparna Rajpurkar, Xiaoqin Xu, Paul A. Ginno, Yoong Wearn Lim, Stella R. Hartono, Frédéric Chédin, Sandra Steyaert, Lionel A. Sanz
Publikováno v:
Molecular cell, vol 63, iss 1
R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific methodology in human and mouse cell types. R-loops are prevalent, coll
Publikováno v:
Molecular Cell. 62:327-334
The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key stu
Autor:
Ziyang Hao, Lulu Hu, Li-Sheng Zhang, Kai-Wen Hsu, Xiaoyang Dou, Jianzhao Liu, Pei-Hua Peng, Allen C. Zhu, Chuan He, Xiaolong Cui, Hui-Lung Sun, Cai-Ping Tan, Yueh-Te Lin, Tong Wu, Pingping Zhu, Kou-Juey Wu, Yawei Gao
Publikováno v:
Mol Cell
N6-Methyldeoxyadenosine (6mA) has recently been shown to exist and play regulatory roles in eukaryotic genomic DNA (gDNA). However, the biological functions of 6mA in mammals have yet to be adequately explored, largely due to its low abundance in mos