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Publikováno v:
Mol Cell
Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, re
Autor:
Maria Victoria Neguembor, Chao-ting Wu, Maria Pia Cosma, Chiara Vicario, Pablo Aurelio Gómez-García, Laura Martin, Álvaro Castells-García, Melike Lakadamyali, Francesco Sottile, Davide Carnevali, Jumana AlHaj Abed, Jérôme Solon, Ruben Sebastian-Perez, Alba Granados
Publikováno v:
Molecular cell. 81(15)
The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin complexes from which the
RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells
Autor:
Hui Zhou, Zhiquan Wang, Mats Ljungman, Tamas Ordog, Marc S. Wold, Honglian Zhang, Zhiguo Zhang, Haiyun Gan, Jeong Heon Lee
Publikováno v:
Molecular Cell. 65:272-284
The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through a short hairpin RNA (shR
Publikováno v:
Molecular Cell. 64:593-606
The human Mre11/Rad50/Nbs1 (hMRN) complex is critical for the sensing, processing, and signaling of DNA double-strand breaks. The nuclease activity of Mre11 is essential for mammalian development and cell viability, although the regulation and substr
Autor:
Jan Vijg, Ryan R. White
Publikováno v:
Molecular Cell. 63:729-738
DNA double-strand breaks (DSBs) are rare, but highly toxic, lesions requiring orchestrated and conserved machinery to prevent adverse consequences, such as cell death and cancer-causing genome structural mutations. DSBs trigger the DNA damage respons
Autor:
Hanxiao Li, Xingzhi Xu, Siyu Li, Xiaoman Li, Jun Zhan, Jiadong Wang, Patrick Sung, Mei Zhou, Hongquan Zhang, Qinjian Shen, Jianyuan Luo, Shiwei Li, Xiao Albert Zhou, Weibin Wang, Wei-Guo Zhu, Yanfei Huo, Yongtai Bai, Meimei Zhao
Publikováno v:
Molecular cell. 75(6)
MRE11 nuclease forms a trimeric complex (MRN) with RAD50 and NBS1 and plays a central role in preventing genomic instability. When DNA double-strand breaks (DSBs) occur, MRN is quickly recruited to the damage site and initiates DNA end resection; acc
Autor:
Robin H. van der Weide, Hans Teunissen, Jelmi uit de Bos, Christian H. Haering, René H. Medema, Mahipal Ganji, Cees Dekker, Eugene Kim, Benjamin D. Rowland, Jorine M. Eeftens, Ahmed M.O. Elbatsh, Sol Bravo, Jonne A. Raaijmakers, Elzo de Wit, Alberto García-Nieto
Publikováno v:
MOLECULAR CELL
Molecular Cell, 76(5)
Molecular Cell
Molecular Cell, 76 (5)
Molecular Cell, 76(5)
Molecular Cell
Molecular Cell, 76 (5)
Summary Condensin is a conserved SMC complex that uses its ATPase machinery to structure genomes, but how it does so is largely unknown. We show that condensin’s ATPase has a dual role in chromosome condensation. Mutation of one ATPase site impairs
Autor:
Stephanie Munk, Mark G. Frattini, Amnon Koren, Jesper V. Olsen, Camille Gelot, Ruth Santos, Kelly A. George, Yoshitaka Kawasoe, Tatsuro S. Takahashi, Prasad V. Jallepalli, Steven A. McCarroll, Mathew J. K. Jones
Publikováno v:
Mol Cell
Jones, M J K, Gelot, C, Munk, S, Koren, A, Kawasoe, Y, George, K A, Santos, R E, Olsen, J V, McCarroll, S A, Frattini, M G, Takahashi, T S & Jallepalli, P V 2021, ' Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication ', Molecular Cell, vol. 81, no. 3, pp. 426-441.e8 . https://doi.org/10.1016/j.molcel.2021.01.004
Jones, M J K, Gelot, C, Munk, S, Koren, A, Kawasoe, Y, George, K A, Santos, R E, Olsen, J V, McCarroll, S A, Frattini, M G, Takahashi, T S & Jallepalli, P V 2021, ' Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication ', Molecular Cell, vol. 81, no. 3, pp. 426-441.e8 . https://doi.org/10.1016/j.molcel.2021.01.004
Eukaryotic genomes replicate via spatially and temporally regulated origin firing. Cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) promote origin firing, whereas the S phase checkpoint limits firing to prevent nucleotide and RPA exhaust
Autor:
Clara Aicart-Ramos, Fernando Moreno-Herrero, Pilar Gutiérrez-Escribano, Holger B. Kramer, Juri Rappsilber, Alex Montoya, Roger Solé-Soler, Kyle L. Morris, Silvia Hormeño, Jordi Torres-Rosell, Francis J. O’Reilly, Luis Aragón, Julene Madariaga-Marcos, Ricardo Aramayo
Publikováno v:
Molecular Cell
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Gutierrez-Escribano, P, Hormeño, S, Madariaga-Marcos, J, Solé-Soler, R, O’Reilly, F J, Morris, K, Aicart-Ramos, C, Aramayo, R, Montoya, A, Kramer, H, Rappsilber, J, Torres-Rosell, J, Moreno-Herrero, F & Aragon, L 2020, ' Purified Smc5/6 complex exhibits DNA substrate recognition and compaction ', Molecular Cell, vol. 80, no. 6, pp. 1039-1054.e6 . https://doi.org/10.1016/j.molcel.2020.11.012
Digital.CSIC. Repositorio Institucional del CSIC
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Gutierrez-Escribano, P, Hormeño, S, Madariaga-Marcos, J, Solé-Soler, R, O’Reilly, F J, Morris, K, Aicart-Ramos, C, Aramayo, R, Montoya, A, Kramer, H, Rappsilber, J, Torres-Rosell, J, Moreno-Herrero, F & Aragon, L 2020, ' Purified Smc5/6 complex exhibits DNA substrate recognition and compaction ', Molecular Cell, vol. 80, no. 6, pp. 1039-1054.e6 . https://doi.org/10.1016/j.molcel.2020.11.012
Digital.CSIC. Repositorio Institucional del CSIC
Repositorio Abierto de la UdL
Universitad de Lleida
Summary Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power a plethora of functions requiring organization and restructuring of eukaryotic chromosomes in interphase and during mitosis. The Smc5/6 mechanism of action
Autor:
Isaac K. Nardi, Madison E. Stellfox, Daniel R. Foltz, Christina M. Knippler, Ewelina Zasadzińska
Publikováno v:
Molecular Cell. 61(5):774-787
Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is