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Autor:
Isaac K. Nardi, Madison E. Stellfox, Daniel R. Foltz, Christina M. Knippler, Ewelina Zasadzińska
Publikováno v:
Molecular Cell. 61(5):774-787
Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is
Publikováno v:
Molecular Cell. 61(3):419-433
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but the mechanism remains elusive. Here we show that FBXW7 facilitates nonhomologous end-joining
Autor:
Markus Hassler, Indra A. Shaltiel, Marc Kschonsak, Bernd Simon, Fabian Merkel, Lena Thärichen, Henry J. Bailey, Jakub Macošek, Sol Bravo, Jutta Metz, Janosch Hennig, Christian H. Haering
Publikováno v:
Molecular Cell
'Molecular Cell ', vol: 74, pages: 1175-1188 (2019)
'Molecular Cell ', vol: 74, pages: 1175-1188 (2019)
Summary The condensin protein complex plays a key role in the structural organization of genomes. How the ATPase activity of its SMC subunits drives large-scale changes in chromosome topology has remained unknown. Here we reconstruct, at near-atomic
Autor:
Sanchez M. Jarrett, Tom C. M. Seegar, Colin T. Waters, Amelia N. Hallworth, Martha L. Bulyk, Stephen C. Blacklow, Julia M. Rogers
Publikováno v:
Molecular Cell. 74:245-253.e6
Transcription factors (TFs) control gene expression by binding DNA recognition sites in genomic regulatory regions. Although most forkhead TFs recognize a canonical forkhead (FKH) motif, RYAAAYA, some forkheads recognize a completely different (FHL)
Autor:
Nahum Sonenberg, Eigo Suyama, Hironori Adachi, Yvan Martineau, Ze'ev Ronai, Hiroaki Imataka, Yuri V. Svitkin, Pedro Aza-Blanc, Satoshi Mikami, Akiko Yanagiya
Publikováno v:
Molecular Cell. 46:847-858
Translational control of gene expression plays a key role in many biological processes. Consequently, the activity of the translation apparatus is under tight homeostatic control. eIF4E, the mRNA 5′ cap-binding protein, facilitates cap-dependent tr
Autor:
A. Arockia Jeyaprakash, Christian Benda, Elena Conti, Ying Wai Chan, Erich A. Nigg, Anna Santamaria, Uma Jayachandran
Publikováno v:
Molecular Cell. 46(3):274-286
The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is composed of three subunits that function together to establish stable kinetochore-microtubule interactions in concert with the Ndc80 network.
Autor:
Zhongsheng You, Quan Zhu, Linda Z. Shi, Andrew Basilio, Peng Wu, Tony Hunter, Nina Tonnu, Youwei Zhang, Inder M. Verma, Michael W. Berns
Publikováno v:
Molecular Cell. 36:954-969
In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by h
Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry
Autor:
Martha Henze, Juan Méndez, John R. Yates, James A. Wohlschlegel, Li-Chiou Chuang, Steven I. Reed, Leonardo K. Teixeira
Publikováno v:
Molecular Cell. 35:206-216
Cyclin E has been shown to have a role in pre-replication complex (Pre-RC) assembly in cells reentering the cell cycle from quiescence. The assembly of the pre-replication complex, which involves the loading of 6 MCM subunits (Mcm2–7), is a prerequ
Autor:
Jun Qin, Seong-Tae Kim, Pumin Zhang, Xuewen Pan, Beom Jun Kim, Sung Yun Jung, Zhiwei Huang, Yi Wang, Xiaoyong Fu, Tao Yang, Jinglan Zhang, Xiaomin Shi, Junling Jia, Yehua Li
Publikováno v:
Molecular Cell. 31:143-151
Sister chromatid cohesion is normally established in S phase in a process that depends on the cohesion establishment factor Eco1, a conserved acetyltransferase. However, due to the lack of known in vivo substrates, how Eco1 regulates cohesion is not
Autor:
V. Narry Kim, Hye Kyung Kim, Hyun Kyu Song, Soon-Jong Kim, Chung-Mo Park, Hyoun Sook Kim, Sang Jae Lee, Se Won Suh, Byung Gil Lee, Inha Heo, Ji Young Yoon, Olesya Kim, Kyoung Hoon Kim, Hye-Jin Yoon, Sang Kyu Kim, Hyung Ho Lee, Youn-Sung Kim, Dojin Kim
Publikováno v:
Molecular Cell. 27:938-950
The yeast protein Dom34 is a key component of no-go decay, by which mRNAs with translational stalls are endonucleolytically cleaved and subsequently degraded. However, the identity of the endoribonuclease is unknown. Homologs of Dom34, called Pelota,