Zobrazeno 1 - 10
of 774
pro vyhledávání: ''
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Autor:
Marius K. Lemberg, Kvido Strisovsky
Publikováno v:
Molecular Cell. 81:2507-2519
Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degrad
Autor:
Georg E. Winter, Martin G. Jaeger
Publikováno v:
Molecular Cell. 81:1617-1630
Multi-dimensional omics profiling continues to illuminate the complexity of cellular processes. Because of difficult mechanistic interpretation of phenotypes induced by slow perturbation, fast experimental setups are increasingly used to dissect caus
Autor:
Seychelle M. Vos
Publikováno v:
Prof. Seychelle Vos
The influence of genome organization on transcription is central to our understanding of cell type specification. Higher-order genome organization is established through short- and long-range DNA interactions. Coordination of these interactions, from
Autor:
Karole N. D’Orazio, Rachel Green
Publikováno v:
Mol Cell
Eukaryotic cells integrate multiple quality control (QC) responses during protein synthesis in the cytoplasm. These QC responses are signaled by slow or stalled elongating ribosomes. Depending on the nature of the delay, the signal may lead to transl
Publikováno v:
Mol Cell
Accurate DNA replication is constantly threatened by DNA lesions arising from endogenous and exogenous sources. Specialized DNA replication stress response pathways ensure replication fork progression in the presence of DNA lesions with minimal delay
Autor:
Weiping Zou, Weimin Wang
Publikováno v:
Mol Cell
Metabolism reprogramming is critical for both cancer progression and effective immune responses in the tumor microenvironment. Amino acid metabolism in different cells and their cross-talk shape tumor immunity and therapy efficacy in patients with ca
Autor:
Matthew J. Cuneo, Tanja Mittag
Publikováno v:
Cell
Summary Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncove
Publikováno v:
Molecular Cell, 80(2), 193-209
Molecular Cell 80 (2020) 2
Molecular Cell 80 (2020) 2
Summary Understanding the genetic design principles that determine protein production remains a major challenge. Although the key principles of gene expression were discovered 50 years ago, additional factors are still being uncovered. Both protein-c
Publikováno v:
Mol Cell
Molecular cell, vol 80, iss 2
Molecular cell, vol 80, iss 2
The Cdk-Rb-E2F pathway integrates external and internal signals to control progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway are found in most human cancers, and specific cyclin-dependent kinase Cdk4/6 inhibi