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Autor:
Junhai Han, Jian Zuo, Wei Xie, Yuqian Shen, Shuting Xia, An Liu, Shanshan Cheng, Wenhua Liu, Zhengping Jia, Xian Liu, Zi Chao Zhang
Publikováno v:
Molecular cell. 81(7)
Summary Eukaryotic elongation factor 2 (eEF2) mediates translocation of peptidyl-tRNA from the ribosomal A site to the P site to promote translational elongation. Its phosphorylation on Thr56 by its single known kinase eEF2K inactivates it and inhibi
Autor:
Wenqi Wang, Youn Sang Jung, Moon Jong Kim, Jie Zhang, Larisa Litovchick, Junjie Chen, Christopher L. Cervantes, Bingliang Fang, Sung Ho Lee, Sohee Jun, Xiaoshan Zhang, Jae Il Park
Publikováno v:
Molecular Cell
Summary The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by
Publikováno v:
Mol Cell
High telomerase activity is restricted to the blastocyst stage of embryonic development when telomere length is reset, and is characteristic of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). However, the pathways involved in
Autor:
Giselle M. Boukhaled, David G. Brooks, Felipe Campos de Almeida, David Allard, Sajid A. Marhon, David Roulois, Joaquín Arribas, Ilias Ettayebi, Tiago Medina, Parinaz Mehdipour, Gustavo P. Amarante-Mendes, Sandra Pommey, John Stagg, Daniel D. De Carvalho, Helen Loo Yau, Isabela M. Gonzaga, Shu Yi Shen, Ankur Chakravarthy, Christian Klein, Beatriz Morancho, Raymond Chen, Emma Bell, Charles A. Ishak, Rajat Singhania
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
International audience; We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8(+) T cells. In vivo HMA treatment promotes CD8(+) T cell tumor infiltration and suppresse
Autor:
Matthew D. Simon, Nicolle A. Rosa-Mercado, Jesse Rinehart, Maria Apostolidi, Joshua T. Zimmer, Joan A. Steitz
Publikováno v:
Mol Cell
Stress-induced readthrough transcription results in the synthesis of downstream-of-gene (DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular stress remain unknown. Nascent transcription profiles during DoG induction i
Autor:
Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on global public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nu
Autor:
Jérôme O. Rouvière, Søren Lykke-Andersen, Carina Demel, Torben Heick Jensen, Manfred Schmid, Björn Schwalb, Guifen Wu, Kristina Žumer, Patrick Cramer, Ewa Šmidová Molska
Publikováno v:
Lykke-Andersen, S, Žumer, K, Molska, E Š, Rouvière, J O, Wu, G, Demel, C, Schwalb, B, Schmid, M, Cramer, P & Jensen, T H 2021, ' Integrator is a genome-wide attenuator of non-productive transcription ', Molecular Cell, vol. 81, no. 3, pp. 514-529.e6 . https://doi.org/10.1016/j.molcel.2020.12.014
Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the Cleavage and Polyadenylation (CPA) and Integrator (INT) complexes originally found to act at the ends of protein-coding and snRNA genes, respectively. Here we
Publikováno v:
Molecular cell. 80(5)
Primary microRNAs (miRNAs) are the precursors of miRNAs that modulate the expression of most mRNAs in humans. They fold up into a hairpin structure that is cleaved at its base by an enzyme complex known as the Microprocessor (Drosha/DGCR8). While man
Autor:
Igor Ruiz de los Mozos, Garima Khandelwal, Till Bartke, Amandeep Bhamra, Victoria Begley, Rachel Wellman, Javier Herrero, Manuel Tavares, Silvia Surinova, Benjamin M. Foster, Andrey Tvardovskiy, Manuel Beltran, Saulius Lukauskas, Richard G. Jenner, Ambrosius P. Snijders, Lenka Skalska, Peter Faull
Publikováno v:
Mol Cell
Mol. Cell 81, 2944-2959.e10 (2021)
Mol. Cell 81, 2944-2959.e10 (2021)
A number of regulatory factors are recruited to chromatin by specialized RNAs. Whether RNA has a more general role in regulating the interaction of proteins with chromatin has not been determined. We used proteomics methods to measure the global impa
Autor:
Lauren G. Mascibroda, Chad B. Stein, Kai Lieh Huang, David Jee, Karen Adelman, Telmo Henriques, William K. Russell, Nathan D. Elrod, David Baillat, Eric J. Wagner
Publikováno v:
Mol Cell
Efficient release of promoter-proximally paused Pol II into productive elongation is essential for gene expression. Recently, we reported that the Integrator complex can bind paused Pol II and drive premature transcription termination, potently atten