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Publikováno v:
Molecular cell. 81(1)
Summary Among the five KCNQ channels, also known as the Kv7 voltage-gated potassium (Kv) channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 are associated with neurological disorders such as epilepsy, deafness, and n
Autor:
Qian Zhang, Hongxin Guan, Hai Song, Jun Qin, Ailian Wang, Shasha Chen, Dan Zhang, Pinglong Xu, Qirou Wu, Tingbo Liang, Xiaojian Wang, Shengduo Liu, Junxian Wang, Songying Ouyang, Zhengfan Jiang, Jian Zou, Xin-Hua Feng
Publikováno v:
Molecular cell. 80(5)
Mitochondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate. It remains unknown whether innate nucleic acid sensing, the central and general mechanisms of monitoring both microbial invasion and cellular d
Publikováno v:
Mol Cell
Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with transcription elongation and 3’ end formation in mammalian cells, we performed long-read sequenc
Autor:
Neal Rosen, Sarat Chandarlapaty, Sunyana Gadal, Jacob A. Boyer, Radha Mukherjee, Andre Levchenko, Kiran Vanaja, Hilla Solomon
Publikováno v:
Mol Cell
Summary The PI3K pathway regulates cell metabolism, proliferation, and migration, and its dysregulation is common in cancer. We now show that both physiologic and oncogenic activation of PI3K signaling increase the expression of its negative regulato
Autor:
Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on global public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nu
Autor:
Eleonore Toufektchan, John Maciejowski, Patrick von Morgen, Lisa Mohr, Aakanksha Kapoor, Kevan Chu
Publikováno v:
Mol Cell
Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the cytoplasm, leading to chromosome fragmentation and immune activation. Here, we
Autor:
Ruilin Tian, Harold C. Marin, David P. Toczyski, Frances V. Hundley, Nerea Sanvisens Delgado, Kaili L. Carr
Publikováno v:
Molecular cell. 81(6)
The human ubiquitin proteasome system, composed of over 700 ubiquitin ligases (E3s) and deubiquitinases (DUBs), has been difficult to characterize systematically and phenotypically. We performed chemical-genetic CRISPR-Cas9 screens to identify E3s/DU
Autor:
Luke H. Hoeppner, Qi Liu, Zhu Zhu, Ting-You Wang, Rendong Yang, Qi Cao, Li Wang, Scott M. Dehm, Yanan Ren, Sk Kayum Alam
Publikováno v:
Mol Cell
Exitron splicing (EIS) creates a cryptic intron (called an exitron) within a protein-coding exon to increase proteome diversity. EIS is poorly characterized, but emerging evidence suggests a role for EIS in cancer. Through a systematic investigation
Publikováno v:
Mol Cell
Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA phase separation is required to resist negative regulation and allow efficient sensing o
Autor:
Gang Duan, Yanshan Fang, Cong Liu, Kai Zhang, Zhiwei Ma, Qiangqiang Wang, Yongjia Duan, Xue Deng, Jinge Gu, Beituo Qian, Shuang Zhang, Lin Guo, Chen Wang
Publikováno v:
Molecular cell. 79(3)
Summary Despite the prominent role of TDP-43 in neurodegeneration, its physiological and pathological functions are not fully understood. Here, we report an unexpected role of TDP-43 in the formation of dynamic, reversible, liquid droplet-like nuclea