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Autor:
Seychelle M. Vos
Publikováno v:
Prof. Seychelle Vos
The influence of genome organization on transcription is central to our understanding of cell type specification. Higher-order genome organization is established through short- and long-range DNA interactions. Coordination of these interactions, from
Publikováno v:
Mol Cell
Transcription is epigenetically regulated by the orchestrated function of chromatin-binding proteins that tightly control the expression of master transcription factors, effectors, and supportive housekeeping genes required for establishing and propa
Autor:
Henning Urlaub, Seychelle M. Vos, Christian Dienemann, Patrick Cramer, Ying Chen, Momchil Ninov
Publikováno v:
Molecular cell. 81(16)
Summary The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here, we report the cryoelectron microscopy (cryo-EM
Autor:
Nazaret Reverón-Gómez, Massimo Carraro, Yanhong Liu, Liu Chen, Hongyu Bao, Alberto García-Nieto, Colin Hammond, Ivo A. Hendriks, Hongda Huang, Christos Spanos, Michael L. Nielsen, Dinshaw J. Patel, Anja Groth, Juri Rappsilber
Publikováno v:
Molecular Cell
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548.e9 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548.e9 . https://doi.org/10.1016/j.molcel.2021.03.041
Hammond, C M, Bao, H, Hendriks, I A, Carraro, M, García-Nieto, A, Liu, Y, Reverón-Gómez, N, Spanos, C, Chen, L, Rappsilber, J, Nielsen, M L, Patel, D J, Huang, H & Groth, A 2021, ' DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network ', Molecular Cell, vol. 81, no. 12, pp. 2533-2548 . https://doi.org/10.1016/j.molcel.2021.03.041
Summary From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone
Autor:
Friedemann Weber, Jonathan Price, Eric A. Miska, Omer Ziv, Lyudmila A. Shalamova, Tsveta Kamenova, Ian Goodfellow
Publikováno v:
Molecular Cell
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA genomes in nature, coronaviruses are critically dependent on long-distance RN
Autor:
Sousa-Luテュs, R., Dujardin, G., Zukher, I., Kimura, Hiroshi, Weldon, C., Carmo-Fonseca, M., Proudfoot, N. J., Nojima, T.
Publikováno v:
Molecular Cell
Summary Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly because of technical limitations in purifying
Autor:
Martin G. Jaeger, Lucas Farnung, Patrick Cramer, Kristina Žumer, Kerstin C. Maier, Petra Rus, Georg E. Winter
Publikováno v:
Molecular cell. 81(15)
Summary Transcription by RNA polymerase II (RNA Pol II) relies on the elongation factors PAF1 complex (PAF), RTF1, and SPT6. Here, we use rapid factor depletion and multi-omics analysis to investigate how these elongation factors influence RNA Pol II
Publikováno v:
Mol Cell
Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with transcription elongation and 3’ end formation in mammalian cells, we performed long-read sequenc
Autor:
Matthew D. Simon, Nicolle A. Rosa-Mercado, Jesse Rinehart, Maria Apostolidi, Joshua T. Zimmer, Joan A. Steitz
Publikováno v:
Mol Cell
Stress-induced readthrough transcription results in the synthesis of downstream-of-gene (DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular stress remain unknown. Nascent transcription profiles during DoG induction i
Autor:
Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on global public health and economies has heightened awareness about the lack of effective antiviral treatments for human coronaviruses (CoVs). Many current antivirals, notably nu