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Publikováno v:
Molecular Cell. 82:3321-3332
Mitochondrial energetics and respiration have emerged as important factors in how cancer cells respond to or evade apoptotic signals. The study of the functional connection between these two processes may provide insight into following questions old
Autor:
Michelle M, Mitchener, Tom W, Muir
Publikováno v:
Molecular Cell. 82:2925-2938
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now appreciated that somatic missense mutations in histones, the packaging agents of genomic DNA, are often associated with human pathologies, especially cancer. A
Autor:
Yulong, Wei, Ya-Chi, Ho
Publikováno v:
Molecular Cell. 82:4585-4587
Plaza-Jennings et al. applied single-nucleus RNA-seq, sorted neuronal and microglia cells for HiC, and found that chronic HIV infection in the brain induces interferon stimulation in microglia, drives chromatin reconfiguration into a transcriptionall
Autor:
Caiwei Guo, Aaron D. Gitler
Publikováno v:
Molecular Cell. 82:4194-4196
In this issue of Molecular Cell, Gropp et al. identify how the cellular background affects whether or not the Huntington's disease protein will form toxic pathological aggregates, providing insight into selective neuronal vulnerability in neurodegene
Autor:
Shino Murakami, Samie R. Jaffrey
Publikováno v:
Mol Cell
Information in mRNA has largely been thought to be confined to its nucleotide sequence. However, the advent of mapping techniques to detect modified nucleotides has revealed that mRNA contains additional information in the form of chemical modificati
Autor:
Sneha, Saxena, Lee, Zou
Publikováno v:
Mol Cell
Faithful DNA replication is critical for the maintenance of genomic integrity. While the DNA replication machinery is highly accurate, the process of DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic stresses th
Autor:
Einat Zalckvar, Maya Schuldiner
Publikováno v:
Molecular Cell. 82:2228-2235
Metabolism is emerging as a central influencer of multiple disease states in humans. Peroxisomes are central metabolic organelles whose decreased function gives rise to severe peroxisomal diseases. Recently, it is becoming clear that, beyond such rar
Publikováno v:
Mol Cell
tRNA is the most extensively modified RNA in cells. On average, a bacterial tRNA contains 8 modifications per molecule and a eukaryotic tRNA contains 13 modifications per molecule. Recent studies reveal that tRNA modifications are highly dynamic and
Autor:
Wang, Hsiao-Lin V., Corces, Victor G.
Publikováno v:
Mol Cell
Two recent reports (Martinez-Ara et al., 2022; Bergman et al., 2022) explore the compatibility between enhancers and promoters and find that enhancers preferentially activate promoters with low intrinsic activity rather than favoring housekeeping or
Publikováno v:
Molecular Cell. 82:1976-1978
Structures of the reconstituted human inner kinetochore complex by Pesenti et al. (2022) and Yatskevich et al. (2022) raise the question of whether it is the CENP-A nucleosome or the CCAN complex itself that provides the foundation for kinetochore as