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Publikováno v:
Mol Cell
Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, re
Autor:
Clerico, Eugenia M., Gierasch, Lila M.
Publikováno v:
Mol Cell
In the eukaryotic cytosol, the Hsp70 and the Hsp90 chaperone machines work in tandem with the maturation of a diverse array of client proteins. The transfer of nonnative clients between these systems is essential to the chaperoning process, but how i
Publikováno v:
Molecular Cell
Molecular Cell, 2022, 82 (10), pp.1909-1923.e5. ⟨10.1016/j.molcel.2022.03.017⟩
Molecular Cell, 2022, 82 (10), pp.1909-1923.e5. ⟨10.1016/j.molcel.2022.03.017⟩
International audience; The lack of a consensus DNA sequence defining replication origins in mammals has led researchers to consider chromatin as a means to specify these regions. However, to date, there is no mechanistic understanding of how this co
Autor:
Paul Clarke
Publikováno v:
Mol Cell
Aberrant cell proliferation is a hallmark of cancer including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma ste
Publikováno v:
Molecular Cell. 81:3589-3603.e13
Transcription elongation has emerged as a regulatory hub in gene expression of metazoans. A major control point occurs during early elongation before RNA polymerase II (Pol II) is released into productive elongation. Prior research has linked BRD4 wi
Autor:
Xiaoyu Zhu, Sung Yun Jung, Mingjun Bi, Joo-Hyung Lee, Michael J. Bolt, Haoyi Wu, Phuoc T. Nguyen, Naadir Jamal, Guojie Li, Michael A. Mancini, Kuang-Lei Tsai, Joanna Krakowiak, Zhijie Liu, Amedeo Caflisch, Pankaj Singh, Ruoyu Wang, Wenbo Li, Josephine C. Ferreon, Jiaofang Shao, Zian Liao, Elena V. Moroz-Omori, Caleb J. Shi, Ragini Mistry, Feng Xiong, Fabio Stossi
Publikováno v:
Mol Cell
The mechanistic understanding of nascent RNAs in transcriptional control remains limited. Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing (MINT-seq), we characterized the landscapes of N6-methyladenosine (m6A)
Autor:
Seung Soo Kim, John Blenis, Gina Lee, Brian F. Pickering, Sungyun Cho, Norbert Perrimon, Jin H. Park, Long He, Lavina Mathur, Cholsoon Jang, Samie R. Jaffrey, Hong-Wen Tang, Joshua D. Rabinowitz, Sunhee Jung, Sebastien Monette
Publikováno v:
Mol Cell
Molecular cell, vol 81, iss 10
Molecular cell, vol 81, iss 10
Dysregulated mTORC1 signaling alters a wide range of cellular processes, contributing to metabolic disorders and cancer. Defining the molecular details of downstream effectors is thus critical for uncovering selective therapeutic targets. We report t
Publikováno v:
'Molecular Cell ', vol: 81, pages: 1246-1259 (2021)
Molecular Cell
Molecular Cell
Summary The Integrator is a specialized 3′ end-processing complex involved in cleavage and transcription termination of a subset of nascent RNA polymerase II transcripts, including small nuclear RNAs (snRNAs). We provide evidence of the modular nat
Autor:
Deanna Tiek, Anshika Goenka, Chang Zeng, Tianzhi Huang, Charles David James, Craig Horbinski, Ichiro Nakano, Shi Yuan Cheng, Yongyong Yang, Xuechao Wan, Wei Xu, Erik P. Sulman, Roger Stupp, John A. Kessler, Bingli Wu, Ryo Nishikawa, Namratha Sastry, Wei Zhang, Xiao Song, Cameron Brennan, Fabao Liu, Bo Hu
Publikováno v:
Molecular Cell. 81:1276-1291.e9
Aberrant cell proliferation is a hallmark of cancer, including glioblastoma (GBM). Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma st
RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells
Autor:
Hui Zhou, Zhiquan Wang, Mats Ljungman, Tamas Ordog, Marc S. Wold, Honglian Zhang, Zhiguo Zhang, Haiyun Gan, Jeong Heon Lee
Publikováno v:
Molecular Cell. 65:272-284
The histone chaperone HIRA is involved in depositing histone variant H3.3 into distinct genic regions, including promoters, enhancers, and gene bodies. However, how HIRA deposits H3.3 to these regions remains elusive. Through a short hairpin RNA (shR