Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andres J. Klein-Szanto"'
Publikováno v:
Molecular Carcinogenesis. 56:1182-1188
Proprotein convertases (PCs) are serine proteases with an active role in the post-translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Publikováno v:
Molecular Carcinogenesis. 54:698-706
Proprotein convertases (PC), a family of serine proteases, process cancer-related substrates such as growth factors, growth factor receptors, cell adhesion molecules, metalloproteinases, etc. HIF-1α is a major transcription factor involved in tumori
Publikováno v:
Molecular Carcinogenesis. 44:151-161
Proprotein convertases (PCs) are a group of Ca2+-dependent serine proteases that have homology to the endoproteases subtilisin (bacteria) and kexin (yeast). This group is comprised of less than a dozen members, known as furin/PACE, PC1/PC3, PC2, PC4,
Autor:
Arthur S. Patchefsky, Íñigo López de la Osa, Shi Yu Zhang, Andres J. Klein-Szanto, Javier Mercapide, José Schneider, Javier S. Castresana, Vicente Furio-bacete, Xing Fan
Publikováno v:
Molecular Carcinogenesis. 35:6-12
Because of the relatively low incidence of lobular breast carcinoma, there are very few studies on the molecular characteristics of this breast cancer. In an attempt to improve its characterization, we investigated in a large collection of invasive l
Autor:
Shao Chen Liu, Dana Holoran, Claudio J. Conti, Daniel E. Bassi, Andres J. Klein-Szanto, Shi Yu Zhang
Publikováno v:
Molecular Carcinogenesis. 34:131-139
Overexpression of cyclin D2 was studied in 10 human squamous cell carcinoma lines, to establish whether this gene plays a role in tumor progression. We found that those cell lines that overexpressed cyclin D2 (CCND2) had the most invasive in vivo beh
Publikováno v:
Molecular carcinogenesis. 54(10)
PACE4 (PCSK6) is a pro-protein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated wh
Publikováno v:
Molecular Carcinogenesis. 28:63-69
Processing of latent precursor proteins by proprotein convertases (PCs) into their biologically active products is a common mechanism required for many important biologic functions. This process is tightly regulated, leading to the generation of acti
Autor:
Andres J. Klein-Szanto, Meenhard Herlyn, John T. Seykora, Robert Lloyd Binder, Tamara Goodrow, Edward R. Sauter, Ercem S. Atillasoy, Kathleen T. Montone
Publikováno v:
Molecular Carcinogenesis. 23:168-174
We previously demonstrated that precancers (actinic keratoses and dysplasias) and squamous cell carcinomas (SCCs) develop in one quarter of human neonatal foreskins grafted onto recombinase-activating gene-1-knockout mice treated once with 7,12-dimet
Publikováno v:
Molecular Carcinogenesis. 18:142-152
Cyclins and cyclin-dependent kinases (Cdks) are central to regulation of the cell cycle. Their abnormal expression may cause loss of cell-cycle control and result in autonomous cell growth, a critical feature of neoplasias. In this study, using immun