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Autor:
Maksudul Alam, Caden O Maxwell, Janmaris Marin Fermin, Tara Moore-Medlin, Cherie-Ann O. Nathan, Chaning Burnett, Alok R. Khandelwal, Patrick T. Spiller, Xiaohua Rong
Publikováno v:
Molecular Carcinogenesis. 61:33-44
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activat
Publikováno v:
Molecular Carcinogenesis. 60:620-626
Genome-wide association study recently identified a novel antiviral gene INTS10 (index rs7000921) in suppression of hepatitis B virus (HBV) replication. However, data were lacking on single nucleotide polymorphisms (SNPs) of INTS10 in the context of
Autor:
Andrew P. Bradford, Elizabeth R. Woodruff, Benjamin G. Bitler, Rebecca J. Wolsky, Lubna Qamar, Marisa R. Moroney, Bradley R. Corr
Publikováno v:
Molecular Carcinogenesis. 60:511-523
The role of β-catenin/TCF transcriptional activity in endometrial cancer (EC) recurrence is not well understood. We assessed the impact of Wnt/β-catenin inhibition in EC models. In an analysis of the Cancer Genome Atlas, we confirmed that CTNNB1 mu
Autor:
Sharon Sams, Laura A. Pike, Veronica L Espinoza, Christopher D. Raeburn, Philip Reigan, Rebecca E. Schweppe, Daniel V. LaBarbera, Nikita Pozdeyev, Hannah M Hicks, Logan R McKenna
Publikováno v:
Molecular Carcinogenesis. 60:201-212
Mutations in the BRAF gene are highly prevalent in thyroid cancer. However, the response rate of thyroid tumors to BRAF-directed therapies has been mixed. Increasingly, combination therapies inhibiting the MAPK pathway at multiple nodes have shown pr
Autor:
Calogero Saieva, Ines Zanna, Sara Raimondi, Saverio Caini, Emilia Cocorocchio, Giovanna Masala, Ignazio Stanganelli, Paola Queirolo, Sara Gandini, Daniela Massi
Publikováno v:
Molecular Carcinogenesis. 60:167-171
Germline variants of the melanocortin-1-receptor (MC1R) gene are the most common genetic trait predisposing to cutaneous melanoma (CM). Here, we performed a literature review and meta-analysis of the association between MC1R gene variants and the fre
Autor:
Dan Chen, Jianzhong Wu, Haixia Cao, Rong Ma, Changwen Jing, Ting Wang, Siwen Liu, Yuan Zhang, Jifeng Feng, Junying Zhang, Zhuo Wang, Yang Wu
Publikováno v:
Molecular Carcinogenesis. 59:478-491
To perform a comprehensive genomic analysis of colorectal cancer (CRC) tumor to detect genetic variants and identify novel resistant mutations associated with cetuximab-resistance in CRC patients. A retrospective study was performed using whole exome
Autor:
Wei Li, Shaojin You, Shuya He, Qiong Chen, Baishuang Yang, Xi Chen, Anqi Guan, Xiaoxiao Lu, Mingxuan Xie, Jian Xiao
Publikováno v:
Molecular Carcinogenesis. 59:179-192
The discovery of epidermal growth factor receptor (EGFR) mutations has made EGFR tyrosine kinase inhibitors (EGFR-TKIs) a milestone in the treatment for advanced non-small cell lung cancer (NSCLC). However, patients lacking EGFR mutations are not sen
Autor:
Leah Cohen, Kenneth Y. Tsai
Publikováno v:
Molecular Carcinogenesis. 58:1602-1611
Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initia
Publikováno v:
Molecular Carcinogenesis. 58:588-602
We have extensively studied the phenotypic heterogeneity of patient-derived melanoma cells. Here, whole-exome sequencing revealed novel variants of genes associated with the MAPK, NOTCH, Hippo, cell-cycle, senescence, and ubiquitin-dependent pathways
Autor:
Virginia de la Cruz, Eva Esteban-Cardeñosa, Carolina Velázquez, Carmen D. Lobatón, Luis E. Abella, Mercedes Durán, Enrique Lastra, Mar Infante
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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BRIP1 is a component of the Fanconi Anemia/BRCA pathway responsible for DNA reparation via helicase activity. Some heterozygous variants in BRIP1 could contribute to Hereditary Breast Cancer through a defective DNA repair. The clinical utility of BRI