Zobrazeno 51 - 60
of 229
pro vyhledávání: '"11"'
Autor:
Zachariah Payne Sellers, Andrew J. Morris, Ahmed Abdel-Latif, Mariusz Z. Ratajczak, Gabriela Schneider
Publikováno v:
Molecular Cancer Research. 12:1560-1573
Bioactive lipids are fundamental mediators of a number of critical biologic processes such as inflammation, proliferation, and apoptosis. Rhabdomyosarcoma (RMS) is common in adolescence with histologic subtypes that favor metastasis. However, the fac
Autor:
Qiuhua Deng, Chun Liang, Ziyi Wang, Hui Pan, Dakai Xiao, Liyan Huang, Yongxin Zou, Jiangfen Zhou, Weixuan Lin, Xin Zhang, Jianxing He
Publikováno v:
Molecular Cancer Research. 12:1535-1546
Cancer is characterized by mutations, genome rearrangements, epigenetic changes, and altered gene expression that enhance cell proliferation, invasion, and metastasis. To accommodate deregulated cellular proliferation, many DNA replication-initiation
Autor:
Eric R. Prossnitz, Chinnasamy Ramesh, Tapan K. Nayak, Jeffrey P. Norenberg, Jeffrey B. Arterburn, Helen J. Hathaway
Publikováno v:
Molecular Cancer Research. 12:1635-1643
Our understanding of estrogen (17β-estradiol, E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein–coupled estrogen receptor (GPER/GPR30) and the development of GPER-selec
Autor:
Arya Sobhakumari, Laurie Love-Homan, Elise V.M. Fletcher, Andrean L. Simons, Apollina Goel, Adam T. Koch, Charlotte R. Feddersen
Publikováno v:
Molecular Cancer Research. 11:1574-1584
Chronic inflammation plays a fundamental role in tumor promotion, migration, and invasion. With the use of microarray profiling, a profound increase was observed for those transcripts involved in proinflammatory signaling in epidermal growth factor r
Publikováno v:
Molecular Cancer Research. 11:1554-1563
p53 is one of the most important tumor suppressor genes, and it is frequently inactivated in various cancers. p53 modulates various cellular functions, such as apoptosis and cell-cycle arrest via transcriptional regulation. Recently, p53 has been rep
Autor:
Dae Joon Kim, Thomas J. Slaga, Huiyun Liang, Anna Mancha, Sung Jen Wei, Gunjan Malik, Jacob J. Junco
Publikováno v:
Molecular Cancer Research. 11:1521-1529
Ursolic acid, present in apples, rosemary, and other sources, is known to inhibit tumor formation and tumor cell viability in multiple systems, including skin. However, various cancers are resistant to ursolic acid treatment. Herein, skin carcinoma c
Publikováno v:
Molecular Cancer Research. 11:1487-1496
DPP8 and DPP9 are recently identified members of the dipeptidyl peptidase IV (DPPIV) enzyme family, which is characterized by the rare ability to cleave a post-proline bond two residues from the N-terminus of a substrate. DPP8 and DPP9 have unique ce
Autor:
Christian Rainer Wirtz, Thomas Simmet, Neil O. Carragher, Matthias Schneider, Mike-Andrew Westhoff, Shaoxia Zhou, Max G. Bachem, Georg Karpel-Massler, Bernd Baumann, Lisa Nonnenmacher, Alexander Krause, Marc-Eric Halatsch, Claudia Jennewein, Klaus-Michael Debatin
Publikováno v:
Molecular Cancer Research. 11:1611-1623
Glioblastoma multiforme, the most common primary brain tumor, is highly refractory to therapy, mainly due to its ability to form micrometastases, which are small clusters or individual cells that rapidly transverse the brain and make full surgical re
Autor:
Kiranjit K. Dhillon, Jen-Wei Huang, Emily Villegas, Patrick S. Mitchell, Christopher J. Kemp, Philamer Calses, Toshiyasu Taniguchi, Yemin Wang, Muneesh Tewari
Publikováno v:
Molecular Cancer Research. 11:1564-1573
Homologous recombination mediates error-free repair of DNA double-strand breaks (DSB). RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors including RAD51, its paralogs, and br
Publikováno v:
Molecular Cancer Research. 11:1624-1635
Protein kinase Cι (PKCι) has oncogenic potential and is an attractive therapeutic target for treatment of lung cancer, particularly those tumors that express elevated PKCι. However, whether PKCι is a viable target in ovarian cancer is unknown, an