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Autor:
Byung-Gyu Kim, Hye Jin Ham, Jung-Guk Kim, Ji-Hyun Kim, Soo-Young Park, Keun-Gyu Park, Jung Yi Lee, Yeon-Kyung Choi, Se Young Jang, Mi Jin Kim, Hui-Jeon Jeon, Inkyu Lee
Publikováno v:
Molecular Cancer Research. 15:1230-1242
The tyrosine kinase inhibitor sorafenib is the only therapeutic agent approved for the treatment of advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is high. Here, we report metabolic reprogramming in sorafenib-resistant
Autor:
Maria E. Arcila, Efsevia Vakiani, Jaclyn F. Hechtman, Jason T. Huse, Jinru Shia, Laetitia Borsu, Rona Yaeger, Justyna Sadowska, Marc Ladanyi
Publikováno v:
Molecular Cancer Research. 13:1003-1008
The PI3K/AKT/mTOR pathway is activated through multiple mechanisms in colorectal carcinoma. Here, the clinicopathologic and molecular features of AKT1 E17K–mutated colorectal carcinoma in comparison with PIK3CA-mutated colorectal carcinoma are desc
Autor:
Andrew Weickhardt, Diego D'Ávila Paskulin, Teresa Nguyen, Dara L. Aisner, Robert C. Doebele, Fiona Chionh, Niall C. Tebbutt, Jenny Hardingham, Anh T. Le, Nathan Schulte, Marileila Varella-Garcia, John M. Mariadason, Jerry Haney
Publikováno v:
Molecular Cancer Research. 12:111-118
Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene fusions, have been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearran
Autor:
Norio Nonomura, Koji Hatano, Mutsumi Tsuchiya, Masashi Nakayama, Souhei Yamaguchi, Akira Nagahara, Kazutoshi Fujita, Yasutomo Nakai, Motohide Uemura, Keisuke Nimura, Yasufumi Kaneda, Kouki Murakami
Publikováno v:
Molecular Cancer Research. 11:1088-1100
Despite an increasing prevalence of patients with docetaxel-refractory prostate cancer, little is known about the tumor biology of the docetaxel-resistant residual tumor cells compared with primary tumor cells. In this study, tumorigenic potential wa
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra
Autor:
Satoru Takahashi, Kouji Hoshino, Yoshinobu Kubota, Hitoshi Ishiguro, Hiroji Uemura, Yukari Ishiguro
Publikováno v:
Molecular Cancer Research. 6:250-258
Angiotensin II has been shown to be a cytokine especially acting as a growth factor. A local renin-angiotensin system has been identified in the prostate gland, and the physiologic function of angiotensin II seems to be similar in prostate cancer, as