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Autor:
Ana M. Plutín, Edson Luis Maistro, Amanda Blanque Becceneri, Alzir A. Batista, Cecília Patrícia Popolin, Márcia Regina Cominetti
Publikováno v:
Molecular Cancer Research. 16:A16-A16
Cancer remains a major public health problem, accounting for one in six deaths worldwide. One of the most common types of cancer in women is breast cancer, which is extremely heterogeneous and composed of different subtypes. The majority of drugs cur
Autor:
Satoru Takahashi, Kouji Hoshino, Yoshinobu Kubota, Hitoshi Ishiguro, Hiroji Uemura, Yukari Ishiguro
Publikováno v:
Molecular Cancer Research. 6:250-258
Angiotensin II has been shown to be a cytokine especially acting as a growth factor. A local renin-angiotensin system has been identified in the prostate gland, and the physiologic function of angiotensin II seems to be similar in prostate cancer, as
Autor:
Sourav Bandyopadhyay, Hsien-Ming Hu
Publikováno v:
Molecular Cancer Research. 15:PR07-PR07
Nearly every cancer patient, especially those with highly lethal and aggressive tumor types, is treated with cytotoxic chemotherapy. Currently, the selection of chemotherapy is based on average responses over a large number of patients. This belies o
Autor:
Mirko Marabese, Elisa Caiola, Massimo Broggini, Marina Chiara Garassino, Gabriella Farina, Roberta Frapolli
Publikováno v:
Molecular Cancer Research. 12:A54-A54
Background: KRAS is one of the best characterized genes in cancer but, despite great efforts made in the past three decades, it remains practically undruggable. KRAS is frequently mutated in the three first cancer leading cause of death in the wester