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Autor:
Yu Shyr, Li-Ching Huang, Charalambos C. Solomides, Yunguang Sun, Adam P. Dicker, Yong Antican Wang, Joshua D. Palmer, Bo Lu
Publikováno v:
Molecular Cancer Research. 15:896-904
Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are associated with various cancers and that IGFBP3 expression is significa
Publikováno v:
Molecular Cancer Research. 13:659-669
KRAS mutations are frequently detected in human colorectal cancer and contribute to de novo apoptosis resistance and ultimately therapeutic failure. To overcome KRAS-mediated apoptosis resistance, the irreversible proteasome inhibitor, carfilzomib, w
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra
Autor:
Cinthia Rosemblit, Brian J. Czerniecki
Publikováno v:
Molecular Cancer Research. 14:B67-B67
Background: We have demonstrated there is a loss of anti-HER-2 Th1 response during tumorigenesis in HER-2pos breast cancer. Maintenance of this response is associated with complete response to neoadjuvant therapy and prolonged disease free survival.