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Autor:
Yangchen Liu, Yongqian Shu, Yongguo Shi, Li Wang, Jie Ding, Juan Li, Yun Tian, Keming Wang, Yingrui Fan, Yifan Lian
Publikováno v:
Molecular Cancer
Background Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes, such as cell growth and apoptosis. The SPRY4 intronic transcript 1 (SPRY4-IT1) is a 708-bp lncRNA on chromosome 5 with a potentia
Autor:
Jürgen Veeck, Edgar Jost, Arndt Hartmann, Edgar Dahl, Ruth Knüchel, Nuran Bektas, Erik Noetzel
Publikováno v:
Molecular Cancer
Molecular cancer 7(83), (2008). doi:10.1186/1476-4598-7-83
Molecular Cancer, Vol 7, Iss 1, p 83 (2008)
Molecular cancer 7(83), (2008). doi:10.1186/1476-4598-7-83
Molecular Cancer, Vol 7, Iss 1, p 83 (2008)
BackgroundWe have previously reported that expression of the Wnt antagonist genesSFRP1andSFRP5is frequently silenced by promoter hypermethylation in breast cancer. SFRP2 is a further Wnt inhibitor whose expression was recently found being downregulat
Autor:
Dezheng Huo, Andrey Khramtsov, Shiyao Wang, Jaxk Reeves, Olufunmilayo I. Olopade, Xinyu Liu, Melissa Davis
Publikováno v:
Molecular Cancer
Background Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a
Autor:
Maria Aparecida Nagai, Thaiomara A. Silva, Jônatas Bussador do Amaral, João de Jesus Viana Pinheiro, Ruy Gastaldoni Jaeger, F. R. R. Mangone, Emerson de Souza Santos, Gláucia Maria Machado-Santelli, Vanessa Morais Freitas
Publikováno v:
Molecular Cancer
Background ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohist