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Autor:
Rose, Michael, Kloten, Vera, Weiskirchen, Ralf, Klaas, Oliver, Antonopoulos, Wiebke, Lin, Qiong, Wagner, Wolfgang, Veeck, Jürgen, Gremse, Felix, Steitz, Julia, Knüchel-Clarke, Ruth, Dahl, Edgar, Noetzel, Erik Alexander, Gola, Lukas, Ehling, Josef Ludger Anton, Heide, Timon, Meurer, Steffen K., Gaiko-Shcherbak, Aljona, Sechi, Antonio S., Huth, Sebastian
Publikováno v:
Molecular Cancer
Molecular cancer 16(1), 44 (2017). doi:10.1186/s12943-017-0610-2
Molecular cancer 16(1), 44 (2017). doi:10.1186/s12943-017-0610-2
Molecular cancer 16(1), 44 (2017). doi:10.1186/s12943-017-0610-2
Published by Biomed Central, London
Published by Biomed Central, London
Autor:
Lan Xiaopeng, Xiao Zhangwu, Jianwen Que, Qiong Hu, Jian Zhu, Qiaojia Huang, Zhang Rui, Gao Anding, Xie Fu'an, Haikun Wang, Kuancan Liu, Baoshun Lin, Weifeng Huang, Long Zhang
Publikováno v:
Molecular Cancer
Background High levels of SOX2 protein are correlated with increased dissemination of breast cancer. However, the underlying molecular mechanisms are not fully understood. Methods In this study we investigate the role of SOX2 in breast cancer metasta
Autor:
Sujoy Ghosh, Cui Rong Teo, Emmanuel Beillard, Wei Zhou, Patrick J. Casey, Suhail Ahmed Kabeer Rasheed, P. Mathijs Voorhoeve
Publikováno v:
Molecular Cancer
Background Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). Our recent study showed that control of GNA13 expression by specific microRNAs (miRNAs or miRs) is
Publikováno v:
Molecular Cancer
Background Restin belongs to MAGE superfamily and is known as MAGE H1. Restin was firstly cloned from HL-60 cells treated with all-trans retinoic acid (ATRA). Previous studies showed a pro-apoptotic role of Restin in several cell lines. However, litt
Autor:
Amita Sneh, Ramesh K. Ganju, Yadwinder S. Deol, Tasha Wilkie, Mustafa M. Basree, Mohd W. Nasser, Akaansha Ganju, Helong Zhao
Publikováno v:
Molecular Cancer
S100A7 (Psoriasin) is an inflammatory protein known to be upregulated in breast cancer. However, the role of S100A7 in breast cancer has been elusive, since both pro- and anti-proliferative roles have been reported in different types of breast cancer
Autor:
Mark M. Schneider, Nichole Peterson, Sandip SenGupta, Jennifer M Roche, Rachel E. Rubino, Christopher J. Nicol, Anthony J. Apostoli, Michael Di Lena
Publikováno v:
Molecular Cancer
Background Among women worldwide, breast cancer is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths. Improved understanding of breast tumourigenesis may facilitate the development of more effective therapies.
Autor:
Sashko Damjanovski, Hon S. Leong, Jacob J. H. Pelling, Jessica A. Willson, Zoey Freedman, Ioana Stan, Karla C. Williams, Caitlin L. Evered, Mario A. Cepeda
Publikováno v:
Molecular Cancer
Paediatrics Publications
Paediatrics Publications
Background Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow migration of cells through the b
Autor:
Abdullah Alsuliman, Hanaa Fitwi, Asma Tulbah, Taher Al-Tweigeri, Monther Al-Alwan, Hazem Ghebeh, Olfat Al-Harazi, Dilek Colak
Publikováno v:
Molecular Cancer
Background The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 expression in this group of patients is still not well-identified. Methods W
Autor:
Yangchen Liu, Yongqian Shu, Yongguo Shi, Li Wang, Jie Ding, Juan Li, Yun Tian, Keming Wang, Yingrui Fan, Yifan Lian
Publikováno v:
Molecular Cancer
Background Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes, such as cell growth and apoptosis. The SPRY4 intronic transcript 1 (SPRY4-IT1) is a 708-bp lncRNA on chromosome 5 with a potentia
Publikováno v:
Molecular Cancer
Background Heat shock protein 90 (Hsp90) is a promising therapeutic target and inhibition of Hsp90 will presumably result in suppression of multiple signaling pathways. FW-04-806, a bis-oxazolyl macrolide compound extracted from China-native Streptom