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Autor:
Mechthild Hatzfeld, Monika Haemmerle, Markus Glaß, Tony Gutschner, Matthias Kappler, W.G. Ballhausen, Alexander W. Eckert, Lisa Müller, Jonas Weiße, Julia Rosemann, Danny Misiak, Stefan Hüttelmaier
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumors are com
Autor:
Jeong A Bae, Ik Joo Chung, Kyung Keun Kim, Hyung-Ho Ha, Keon Young Kim, So-Yeon Park, Yoo-Seung Ko, Eun Ae Kim, Woo Kyun Bae, Young Hyun Yu, Sung Jin Kim, Hangun Kim
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-24 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-24 (2021)
Background Distant metastasis is the major cause of death in patients with colorectal cancer (CRC). Previously, we identified KITENIN as a metastasis-enhancing gene and suggested that the oncogenic KITENIN complex is involved in metastatic disseminat
Autor:
Marek Michalak, Yongxiang Yi, Huang Yuan, Jingfeng Tang, Zhou Cefan, Qin Wenying, Yanan Yan, Rui Zhang, Xueying Dong, Xing-Zhen Chen, Jie Wei, Declan W. Ali, Changhua Yi, Xuewen Zhang
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 19, Iss 1, Pp 1-24 (2020)
Molecular Cancer, Vol 19, Iss 1, Pp 1-24 (2020)
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 was reported to be involved in
Autor:
Lili Wang, Zhaowei Sun, Weili Duan, Yunshan Wang, Lutao Du, Hui Tian, Chuanxin Wang, Xiaoming Liu, Peilong Li, Yujiao Xie, Xin Zhang, Tong Liu, Yinghui Zhao
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 19, Iss 1, Pp 1-2 (2020)
Molecular Cancer, Vol 19, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Autor:
Zhiwei Quan, Di Zhou, Zhaohui Tang, Mingzhe Weng, Qiang Cai, Jiandong Wang, Shouhua Wang, Longyang Jin
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 18, Iss 1, Pp 1-16 (2019)
Molecular Cancer, Vol 18, Iss 1, Pp 1-16 (2019)
Background Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress. We aimed to investigate the role of l
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 18, Iss 1, Pp 1-18 (2019)
Molecular Cancer, Vol 18, Iss 1, Pp 1-18 (2019)
Background Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) c
Autor:
Junjie Ma, Yunfei Xu, Yonghui Chen, Wei Zhai, Junhua Zheng, Jin Zhang, Wen Kong, Dongkui Gong, Saiyang Li, Wei Xue
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Molecular Cancer, Vol 17, Iss 1, Pp 1-15 (2018)
Purpose Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles in metastatic renal cell carcinoma (mRCC) and Sunitinib treatment was limited. Here we sought to identify
Autor:
Floriana Morgillo, Giuseppe Viscardi, Teresa Troiani, Fortunato Ciardiello, Raimondo Di Liello, Carminia Maria Della Corte, Morena Fasano, Erika Martinelli
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion
Autor:
Cinzia Franchin, Enrico Capobianco, Paolo Sportoletti, Silvia Rocchiccioli, Elena Guzzolino, Nicholas F. Tsinoremas, Monica Evangelista, Laura Poliseno, Alberto Mercatanti, Marianna Vitiello, Giovanni Signore, Giorgio Arrigoni, Simone Lubrano, Andrea Tuccoli, Jessie Villanueva, Ileabett M. Echevarria-Vargas, Laura Comelli, Giorgio Cozza, Letizia Pitto, Zhijie Jiang, Ettore Luzi, Andrea Marranci, Samanta Sarti
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 16, Iss 1, Pp 1-25 (2017)
Molecular Cancer, Vol 16, Iss 1, Pp 1-25 (2017)
Background The BRAF protein kinase is widely studied as a cancer driver and therapeutic target. However, the regulation of its expression is not completely understood. Results Taking advantage of the RNA-seq data of more than 4800 patients belonging
Publikováno v:
Molecular Cancer
Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, a