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Autor:
Floriana Morgillo, Giuseppe Viscardi, Teresa Troiani, Fortunato Ciardiello, Raimondo Di Liello, Carminia Maria Della Corte, Morena Fasano, Erika Martinelli
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Molecular Cancer, Vol 17, Iss 1, Pp 1-9 (2018)
Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion
Autor:
Maricla Galetti, Silvia La Monica, Roberta Alfieri, Costanza Lagrasta, Caterina Frati, Luca Ampollini, Daniele Cretella, Francesca Saccani, Pier Giorgio Petronini, Marcello Tiseo, Federico Quaini, Andrea Ardizzoni, Andrea Cavazzoni, Claudia Fumarola, Cristina Caffarra, Mara A. Bonelli
Publikováno v:
Molecular Cancer
Background: HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence for reported HER-2 overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. Moreover, HER-2 amplification is
Autor:
Qiang Shen, Lemin Zheng, Jun Gao, Fang Gu, Shuying Dong, Qiang-Bo Zhang, Wenbing Sun, Fandong Kong, Hui-Chuan Sun, Shan Ke, Bing Pan, Jian Kong
Publikováno v:
Molecular Cancer
Background Traditional systemic chemotherapy does not provide survival benefits in patients with hepatocellular carcinoma (HCC). Molecular targeted therapy shows promise for HCC treatment, however, the duration of effectiveness for targeted therapies
Autor:
Guillermo Lopez-Vivanco, Unai Aresti, Alberto Muñoz, Aitziber Buqué, Jangi Sh. Muhialdin, Aintzane Sancho, Sergio Carrera, B. Calvo, Itziar Rubio
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 11, Iss 1, p 25 (2012)
Molecular Cancer, Vol 11, Iss 1, p 25 (2012)
Background Metastatic melanoma is a lethal skin cancer and its incidence is rising every year. It represents a challenge for oncologist, as the current treatment options are non-curative in the majority of cases; therefore, the effort to find and/or
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 10, Iss 1, p 106 (2011)
Molecular Cancer, Vol 10, Iss 1, p 106 (2011)
Background Previous studies showed that mesothelin (MSLN) plays important roles in survival of pancreatic cancer (PC) cells under anchorage dependent/independent conditions as well as resistance to chemotherapy. The recent success of intratumorally-i
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 10, Iss 1, p 12 (2011)
Molecular Cancer, Vol 10, Iss 1, p 12 (2011)
Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties inclu
Autor:
Elaine G. Rodrigues, Luiz R. Travassos, Bianca Rachid Dias, Igor C. Almeida, Leonardo Nimrichter, Ernesto S. Nakayasu
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 8, Iss 1, p 116 (2009)
Molecular Cancer, Vol 8, Iss 1, p 116 (2009)
BackgroundCD1d-restricted iNKT cells are protective against murine melanoma B16F10-Nex2 growing subcutaneously in syngeneic C57Bl/6 mice as inferred from the fast tumor development in CD1d-KO in comparison with wild type animals. CD1d glycoproteins a
Autor:
Elizabeth Dimba, Anne Christine Johannessen, Line Wergeland, Olav Karsten Vintermyr, Bjørn Tore Gjertsen, Kjell Ove Fossan, Karl Johan Tronstad, Hanne R. Hagland, Therese Bredholt, Jørn Skavland
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 8, Iss 1, p 101 (2009)
Molecular Cancer, Vol 8, Iss 1, p 101 (2009)
Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side wit