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Autor:
Nerea Urruticoechea, Emil W. Westi, Jens V. Andersen, Blanca I. Aldana, Emil Jakobsen, Karin Borges
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-13 (2021)
Molecular Brain
Andersen, J V, Westi, E W, Jakobsen, E, Urruticoechea, N, Borges, K & Aldana, B I 2021, ' Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply ', Molecular Brain, vol. 14, no. 1, 132 . https://doi.org/10.1186/s13041-021-00842-2
Molecular Brain
Andersen, J V, Westi, E W, Jakobsen, E, Urruticoechea, N, Borges, K & Aldana, B I 2021, ' Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply ', Molecular Brain, vol. 14, no. 1, 132 . https://doi.org/10.1186/s13041-021-00842-2
The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining attention as beneficial brain fuels in several neurological disorders. The protective effects of C8 and C10 have been proposed to be driven by hepatic production of k
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Molecular Brain
Molecular Brain
Insular cortex is a critical brain region that participates in the interoceptive sensations. Here, we combined the iDISCO+ method and Fos immunostaining to confirm that the middle part of the right-side, but not the left-side, insular cortex in adult
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-9 (2021)
Molecular Brain
Molecular Brain
Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized that the chronic pruritus may result from sensitization of itch-signaling pathways but the mechanisms remain obscure. In this study, we establishe
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Molecular Brain
Molecular Brain
Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disease characterized by Aβ accumulation and tau hyperphosphorylation. Epidemiological evidence for a negative correlation between cancer and AD has led to the proposed use of tyrosi
Autor:
Jung-Pyo Oh, Jin-Hee Han
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-9 (2020)
Molecular Brain
Molecular Brain
A unique feature of fear memory is its persistence that is highly relevant to fear and anxiety-related mental disorders. Recurrent reactivation of neural representations acquired from a traumatic event is thought to contribute to the indelibility of
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Molecular Brain
Molecular Brain
Brain injury causes astrocytes to become reactive (astrogliosis). In this study, we compared astrogliosis in acutely injured cortex and striatum of adult FVB/N mice induced by stereotaxic injection of ATP, a component of danger-associated molecular p
Autor:
Arturo Andrade, Marie Akiki, Alexandra Bunda, Kevin G. Bath, Melanie Bertolino, Javier Lopez-Soto, Diane Lipscombe, Brianna LaCarubba
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-14 (2019)
Molecular Brain
Molecular Brain
Presynaptic CaV2.2 channels control calcium entry that triggers neurotransmitter release at both central and peripheral synapses. The Cacna1b gene encodes the α1-pore forming subunit of CaV2.2 channels. Distinct subsets of splice variants of CaV2.2
Autor:
Yanyun Wang, Shuqiang Cao, Weibo Liang, Youjing Jiang, Linbo Gao, He Yan, Lin Zhang, Xiao Xiao
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-12 (2019)
Molecular Brain
Molecular Brain
Ferroptosis, a newly discovered form of iron-dependent regulated cell death, has been implicated in traumatic brain injury (TBI). MiR-212-5p has previously been reported to be downregulated in extracellular vesicles following TBI. To investigate whet
Autor:
Gerald W. Zamponi, Vinicius M. Gadotti
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-3 (2019)
Molecular Brain
Molecular Brain
Anxiety related disorders commonly occur in association with major depressive disorder (MDD) in individuals suffering from peripheral inflammation, with a higher prevalence among IBS patients. We have previously shown that the bioflavonoid luteolin h
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
Autor:
Hyeon Son, Chuljung Kwak, Young Hoon Ji, Hyoung Gon Ko, Deok-Jin Jang, Bong-Kiun Kaang, Yun Sil Lee, Jun Hyeok Choi, Junehee Son
Publikováno v:
Molecular Brain, Vol 2, Iss 1, p 1 (2009)
Molecular Brain
Molecular Brain
Newborn neurons in the subgranular zone (SGZ) of the hippocampus incorporate into the dentate gyrus and mature. Numerous studies have focused on hippocampal neurogenesis because of its importance in learning and memory. However, it is largely unknown