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pro vyhledávání: '"Ying Huang"'
Publikováno v:
Molecular and Cellular Pharmacology. 1:92-97
Sulindac, the non-steroidal anti-inflammatory drug has shown promise in the prevention of colon cancer but the molecular mechanisms by which it mediates such effects remain to be elucidated. Sulindac sulfide is the major active metabolite of sulindac
Autor:
Ki Lui, Ying Huang
Publikováno v:
Molecular and cellular pharmacology. 1(3)
RanGTPase belongs to the Ras superfamily of small GTPases. It possesses a distinctive acidic C-terminal DEDDDL motif and predominantly localizes to the nucleus. RanGTPase is known to regulate nucleocytoplasmic trafficking as well as mitotic spindle a
Publikováno v:
Molecular and cellular pharmacology. 2(2)
Cellular response to DNA damage is multifacted in nature and involves a complex signaling network in which p53 functions as a “molecular node” for converging signals. p53 has been implicated in a variety of cellular processes primarily functionin
Publikováno v:
Molecular and cellular pharmacology. 2(1)
Pirh2 is an E3 ubiquitin ligase that promotes tumor suppressor p53 ubiquitination and proteasomal degradation. Recently, we have reported the identification and characterization of two novel isoforms of Pirh2 named Pirh2B and Pirh2C and accordingly,