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Publikováno v:
Molecular and Cellular Endocrinology. 477:29-38
Cumulus cells and the remodeling of their extracellular matrix around oocytes are essential for oocyte maturation and ovulation in the ovary. An important extracellular metalloprotease, ADAMTS1, and its partner VERSICAN, mediate essential cumulus-ooc
Publikováno v:
Molecular and cellular endocrinology. 525
Background: Previous studies have shown that CCNB1 affects the invasiveness of pituitary adenomas, and it is of great significance to find the upstream mechanism of regulating CCNB1.Methods: RT-qPCR was used to measure the expression of circNFIX and
Publikováno v:
Molecular and cellular endocrinology. 517
Anti-Mullerian hormone (AMH/Amh) plays a role in gonadal differentiation and function across vertebrates. In zebrafish we demonstrated that Amh deficiency caused severe gonadal dysgenesis and dysfunction. The mutant gonads showed extreme hypertrophy
Autor:
Attila Horvath, Jean-François Deleuze, Zoltan Simandi, Ixchelt Cuaranta-Monroy, Laszlo Nagy, Sascha Sauer
Publikováno v:
Molecular and Cellular Endocrinology. 471:51-62
Retinoid X Receptors (RXRs) are unique and enigmatic members of the nuclear receptor (NR) family with extensive and complex biological functions in cellular differentiation. On the one hand, RXRs through permissive heterodimerization with other NRs a
Autor:
Yoshitaka Nagahama, Kaoru Ohno, Masatoshi Nakamoto, Penny Swanson, Yoshihito Taniguchi, Yasuhiro Kamei, Takashi Sakamoto, Kiyoshi Naruse, Graham Young, Takeshi Todo, Yasushi Shibata, Takeshi Usami
Publikováno v:
Molecular and Cellular Endocrinology. 460:104-122
Although estrogens have been generally considered to play a critical role in ovarian differentiation in non-mammalian vertebrates, the specific functions of estrogens during ovarian differentiation remain unclear. We isolated two mutants with prematu
Autor:
Fei Yan, Zheng Sun, Kai Liang, Xinghong Guo, Jinbang Wang, Wenjuan Li, Yixin Cui, Chen Cui, Huiqing Hu, Fuqiang Liu, Xinguo Hou, Qin He, Jia Song, Li Chen, Ruxing Zhao, Lingshu Wang, Chuan Wang, Nan Zang, Yujing Sun, Mengmeng Yang, Jun Qin
Publikováno v:
Molecular and Cellular Endocrinology. 537:111445
Background α-cell dysregulation gives rise to fasting and postprandial hyperglycemia in type 2 diabetes mellitus(T2DM). Administration of Mesenchymal stem cells (MSCs) or their conditioned medium can improve islet function and enhance insulin secret
Autor:
Carmen Sánchez-Torres, Joseline Janai Hidalgo-Moyle, Erika González-Domínguez, Tania Yareli Gutiérrez-López, Marco Antonio Hernández-Bedolla, Cesar Zavala-Barrera, Guadalupe Reyes-Cruz, José Vázquez-Prado
Publikováno v:
Molecular and Cellular Endocrinology. 436:159-168
IL-6 is a tightly controlled pleiotropic cytokine with hormone-like properties whose levels are frequently altered in cancer and inflammatory diseases. In highly invasive MDA-MB-231 breast cancer cells, basal activity of endogenously expressed calciu
Autor:
Yasuhiro Nakamura, Ryo Morimoto, Kentaro Takanami, Keigo Murakami, Hideki Katakami, Shin-ichi Horike, Fumitoshi Satoh, Seiichi Hirota, Saulo J.A. Felizola, Michiaki Unno, Yoshiyu Takeda, Hironobu Sasano, Makiko Meguro-Horike
Publikováno v:
Molecular and Cellular Endocrinology. 436:268-273
Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II. We report the first case of pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. An 8
Publikováno v:
Molecular and Cellular Endocrinology. 436:169-182
The regulation of the tammar wallaby (Macropus eugenii) early lactation protein (ELP) gene is complex. ELP is responsive to the lactogenic hormones; insulin (I), hydrocortisone (HC) and prolactin (PRL) in mammary gland explants but could not be induc
Publikováno v:
Molecular and cellular endocrinology. 494
MicroRNAs (miRNAs) are a group of negative regulators of gene expression that function at the posttranscriptional level. Dysregulation of miRNAs is involved in many pathophysiological processes, including polycystic ovary syndrome (PCOS). In this stu